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The impact of pregnane X receptor activation on liver fibrosis

Lookup NU author(s): Professor Matthew Wright

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Abstract

The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage - that of fibrosis. The antifibrogenic mode of action is mediated through changes in the expression of genes in hepatic stellate cells and liver macrophages (Kupffers). These results suggest an additional function for the PXR. ©2006 Biochemical Society.

Publication metadata

Author(s): Wright MC

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2006

Volume: 34

Issue: 6

Pages: 1119-1123

Print publication date: 01/01/2006

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0341119

DOI: 10.1042/BST0341119

PubMed id: 17073765

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