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Mechanisms of self-renewal in human embryonic stem cells

Lookup NU author(s): Dr Rebecca Stewart, Professor Miodrag Stojkovic, Professor Majlinda LakoORCiD


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Embryonic stem cells (ESCs) are the pluripotent cell population derived from the inner cell mass of pre-implantation embryos and are characterised by prolonged self-renewal and the potential to differentiate into cells representing all three germ layers both in vitro and in vivo. Preservation of the undifferentiated status of the ESC population requires the maintenance of self-renewal whilst inhibiting differentiation and regulating senescence and apoptosis. In this review, we discuss the intrinsic and extrinsic factors associated with self-renewal process, together with possible signalling pathway interactions and mechanisms of regulation. © 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Stewart R, Stojkovic M, Lako M

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 2006

Volume: 42

Issue: 9

Pages: 1257-1272

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852

Publisher: Pergamon


DOI: 10.1016/j.ejca.2006.01.033

PubMed id: 16630716


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Funder referenceFunder name
BBS/B/14779Biotechnology and Biological Sciences Research Council