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Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases

Lookup NU author(s): Emeritus Professor Harry Gilbert

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Abstract

(Chemical Equation Presented) Pick-a-path: A series of enzymatic snap-shots along the reaction coordinate of a lichenase (specific for gluco-configured substrates) demonstrates that this enzyme uses a different reaction pathway, featuring a 1S3→4H3→ 4C1 migration, to that previously observed for the closely related mannanases. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

Publication metadata

Author(s): Money VA, Smith NL, Scaffidi A, Stick RV, Gilbert HJ, Davies GJ

Publication type: Article

Publication status: Published

Journal: Angewandte Chemie International Edition

Year: 2006

Volume: 45

Issue: 31

Pages: 5136-5140

ISSN (print): 1433-7851

ISSN (electronic): 1521-3773

Publisher: Wiley - VCH Verlag GmbH & Co. KGaA

URL: http://dx.doi.org/10.1002/anie.200600802

DOI: 10.1002/anie.200600802

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