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Lookup NU author(s): Professor Tim Goodship
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Missense mutations in the C-terminal region of Factor H are associated with atypical hemolytic uremic syndrome, whereas homozygous Factor H deficiency is more frequently associated with membranoproliferative glomerulonephritis type II (MPGN II). The report of Licht et al. of a mutation in the complement- regulatory N-terminal region of Factor H in MPGN II provides additional insight into the pathogenesis of this condition.
Author(s): Goodship THJ
Publication type: Review
Publication status: Published
Journal: Kidney International
Year: 2006
Volume: 70
Issue: 1
Pages: 12-13
ISSN (print): 0085-2538
ISSN (electronic): 1523-1755
URL: http://dx.doi.org/10.1038/sj.ki.5001612
DOI: 10.1038/sj.ki.5001612
PubMed id: 16810287
