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Does complement factor B have a role in the pathogenesis of atypical HUS?

Lookup NU author(s): Professor David KavanaghORCiD, Dr Anna Richards, Rachel Burgess, Professor Judith Goodship, Professor Tim Goodship

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Abstract

Atypical haemolytic uraemic syndrome (aHUS) is a disorder of complement dysregulation. Because complement factor B (fB) carries the catalytic site of the alternative pathway convertase we examined it as both a potential candidate gene and modifier in the pathogenesis of aHUS. No factor B gene (BF) mutations were found in 20 patients with aHUS. There was no statistical difference between controls and aHUS patients in either BF allele or haplotype frequency. In conclusion, in this small series of aHUS patients we found no evidence that fB has a major role in the pathogenesis of aHUS. © 2005 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Kavanagh D, Kemp EJ, Richards A, Burgess RM, Mayland E, Goodship JA, Goodship THJ

Publication type: Article

Publication status: Published

Journal: Molecular Immunology

Year: 2006

Volume: 43

Issue: 7

Pages: 856-859

ISSN (print): 0161-5890

ISSN (electronic): 1872-9142

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.molimm.2005.06.041

DOI: 10.1016/j.molimm.2005.06.041

PubMed id: 16061287


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