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Non-alcoholic fatty liver disease: Current concepts and management strategies

Lookup NU author(s): Professor Chris Day


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Non-alcoholic fatty liver disease (NAFLD), the liver manifestation of the metabolic syndrome, is now considered to be the commonest liver problem in the western world. This apparent 'epidemic', coupled with an accumulating body of evidence that a significant proportion of patients with NAFLD can progress to cirrhosis, liver failure and hepatocellular carcinoma (HCC), has - perhaps not surprisingly - led to an exponential growth in clinical and basic studies investigating all aspects of this hitherto largely ignored disease. The result is a vast increase in understanding of the natural history, clinical features and pathophysiology of NAFLD over the last five years which has now begun to inform the development of rational management strategies.

Publication metadata

Author(s): Day CP

Publication type: Review

Publication status: Published

Journal: Clinical Medicine, Journal of the Royal College of Physicians of London

Year: 2006

Volume: 6

Issue: 1

Pages: 19-25

ISSN (print): 1470-2118

ISSN (electronic): 1473-4893

PubMed id: 16521351