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Lookup NU author(s): Professor Julia Newton,
Professor Bruce Westley,
Dr Felicity May
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Normal circadian variations in vasoactive intestinal polypeptide, somatostatin, cholecystokinin and pancreatic polypeptide were measured to determine if these alter with aging and to identify gastrointestinal regulatory hormones that might control the dramatic diurnal variation in the gastric cytoprotective trefoil protein TFF2. Plasma pancreatic polypeptide concentrations showed a marked diurnal rhythm (p < 0.0001). Basal and postprandial pancreatic polypeptide concentrations increased with age (p < 0.01). The timing of the diurnal rhythm was consistent with pancreatic polypeptide inhibiting TFF2 secretion and there was a negative association between pancreatic polypeptide and TFF2 concentrations (p < 0.002). The much higher pancreatic polypeptide concentrations in older people will induce increased satiety that may contribute to 'anorexia of ageing'. These results identify potential therapies for treatment of gastric mucosal morbidity and age-associated loss of appetite. © 2005 Elsevier Inc. All rights reserved.
Author(s): Johns C, Newton JL, Westley BR, May FEB
Publication type: Article
Publication status: Published
Print publication date: 01/06/2006
ISSN (print): 0196-9781
ISSN (electronic): 1873-5169
PubMed id: 16359755
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