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Human pancreatic polypeptide has a marked diurnal rhythm that is affected by ageing and is associated with the gastric TFF2 circadian rhythm

Lookup NU author(s): Emerita Professor Julia Newton, Professor Bruce Westley, Dr Felicity May


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Normal circadian variations in vasoactive intestinal polypeptide, somatostatin, cholecystokinin and pancreatic polypeptide were measured to determine if these alter with aging and to identify gastrointestinal regulatory hormones that might control the dramatic diurnal variation in the gastric cytoprotective trefoil protein TFF2. Plasma pancreatic polypeptide concentrations showed a marked diurnal rhythm (p < 0.0001). Basal and postprandial pancreatic polypeptide concentrations increased with age (p < 0.01). The timing of the diurnal rhythm was consistent with pancreatic polypeptide inhibiting TFF2 secretion and there was a negative association between pancreatic polypeptide and TFF2 concentrations (p < 0.002). The much higher pancreatic polypeptide concentrations in older people will induce increased satiety that may contribute to 'anorexia of ageing'. These results identify potential therapies for treatment of gastric mucosal morbidity and age-associated loss of appetite. © 2005 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Johns C, Newton JL, Westley BR, May FEB

Publication type: Article

Publication status: Published

Journal: Peptides

Year: 2006

Volume: 27

Issue: 6

Pages: 1341-1348

Print publication date: 01/06/2006

ISSN (print): 0196-9781

ISSN (electronic): 1873-5169


DOI: 10.1016/j.peptides.2005.11.002

PubMed id: 16359755


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