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Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus

Lookup NU author(s): Professor Mark Cunningham, Professor Miles Whittington


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Cells that produce intrinsic theta oscillations often contain the hyperpolarization-activated current Ih. In this article, we use models and dynamic clamp experiments to investigate the synchronization properties of two such cells (stellate cells of the entorhinal cortex and O-LM cells of the hippocampus) in networks with fast-spiking (FS) interneurons. The model we use for stellate cells and O-LM cells is the same, but the stellate cells are excitatory and the O-LM cells are inhibitory, with inhibitory postsynaptic potential considerably longer than those from FS interneurons. We use spike time response curve methods (STRC), expanding that technique to three-cell networks and giving two different ways in which the analysis of the three-cell network reduces to that of a two-cell network. We show that adding FS cells to a network of stellate cells can desynchronize the stellate cells, while adding them to a network of O-LM cells can synchronize the O-LM cells. These synchronization and desynchronization properties critically depend on Ih. The analysis of the deterministic system allows us to understand some effects of noise on the phase relationships in the stellate networks. The dynamic clamp experiments use biophysical stellate cells and in silico FS cells, with connections that mimic excitation or inhibition, the latter with decay times associated with FS cells or O-LM cells. The results obtained in the dynamic clamp experiments are in a good agreement with the analytical framework. © 2006 Massachusetts Institute of Technology.

Publication metadata

Author(s): Pervouchine DD, Netoff TI, Rotstein HG, White JA, Cunningham MO, Whittington MA, Kopell NJ

Publication type: Article

Publication status: Published

Journal: Neural Computation

Year: 2006

Volume: 18

Issue: 11

Pages: 2617-2650

ISSN (print): 0899-7667

ISSN (electronic): 1530-888X

Publisher: MIT Press


DOI: 10.1162/neco.2006.18.11.2617

PubMed id: 16999573


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