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Orchestration of Vectorial Chloride Transport by Epithelia

Lookup NU author(s): Dr Michael Gray


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Epithelial chloride transport is of vital physiological importance to many tissues and is a process that is tightly regulated by the cell. In the last decade, a combination of biochemical, molecular, and physiological research has furthered our understanding of the major players in epithelial chloride transport, and we are beginning to understand at the atomic level how some of these transporters actually work. It is becoming increasingly clear that effective transepithelial movement of chloride not only requires the coordinated action of a variety of plasma membrane transporters, but also a myriad of associated binding partners. Many of these partners have only recently been discovered, and many more are likely to be found. The dynamic interaction of these multiprotein complexes is now becoming fully appreciated and in the future likely will drive intense research efforts. Dysfunction in salt and fluid absorption or secretion can have dire consequences for the organism, and is known to be the underlying cause of a number of important human diseases. Our current understanding of the physiological function of epithelial chloride channels and transporters, together with the advent of transgenic animals and other molecular/genetic approaches, form the basis for achieving the future insights into the pathophysiology of a variety of diseases. We anticipate these insights will produce new therapies to treat disorders of chloride transport and enhance the quality of life for affected individuals. © 2007 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Fong P, Gray MA

Publication type: Review

Publication status: Published

Journal: Advances in Molecular and Cell Biology

Year: 2006

Volume: 38

Pages: 329-368

ISSN (print): 1569-2558

ISSN (electronic): 1875-5291


DOI: 10.1016/S1569-2558(06)38012-5