Publications by Dr Michael Gray - ePrints

Browsing publications by Dr Michael Gray.

Newcastle Authors	Title	Year
Sara Cuevas Ocaña Dr George Schlossmacher Professor Neil Perkins Dr Michael Gray	A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells	2023
Livia Delpiano Matthew Burke Dr Glyn Nelson Dr Michael Gray	Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations	2023
JinHeng Lin Sean Gettings Professor Michael Taggart Dr Mike Althaus Dr Michael Gray et al.	Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels	2023
Livia Delpiano Dr Michael Gray	Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids	2022
Dr Vinciane Saint-Criq Livia Delpiano Dr Michael Gray	Inhibition of the sodium-dependent HCO₃ - transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype	2022
Livia Delpiano Dr Michael Gray	The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion	2022
JinHeng Lin Professor Michael Taggart Dr Lee Borthwick Professor Andrew Fisher Dr Malcolm Brodlie et al.	Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells	2021
Dr Iram Haq Dr Mike Althaus Dr Vinciane Saint-Criq Dr Bernard Verdon Dr Jen Townshend et al.	Clinical and molecular characterisation of the R751L-CFTR mutation	2021
Dr Michael Gray	CyFi-MAP: an interactive pathway-based resource for cystic fibrosis	2021
Dr Vinciane Saint-Criq Livia Delpiano JinHeng Lin Dr Michael Gray	Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors	2021
Dr Vinciane Saint-Criq Livia Delpiano John Casement Jennifer Chika Onuora Jia-Yu Lin et al.	Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells	2020
Dr Michael White Dr Rashmi Maheshwari Dr Scott Anderson Dr Rolando Berlinguer Palmini Claire Jones et al.	In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas	2020
Dr Aaron Ions Gardner Dr Iram Haq Professor John Simpson Dr Vinciane Saint-Criq Dr Bernard Verdon et al.	Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis	2020
Abi Marklew Waseema Patel Dr Michael Gray	Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum	2019
Waseema Patel Dr Michael Gray	Increases in cytosolic Ca²⁺ induce dynamin- and calcineurin-dependent internalisation of CFTR	2019
Livia Delpiano Dr Michael Gray	Location, location, location: lessons from airway epithelial anion channels	2019
Dr Vinciane Saint-Criq Dr Iram Haq Dr Aaron Ions Gardner Professor Christopher Ward Dr Malcolm Brodlie et al.	Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells	2019
Livia Delpiano Dr Sarah Rice Dr Michael Gray Dr Vinciane Saint-Criq	Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells	2018
Salam Ibrahim Mark Turner Dr Vinciane Saint-Criq Dr James Garnett Dr Iram Haq et al.	CK2 is a key regulator of SLC₄A2- mediated Cl-/HCO₃- exchange in human airway epithelia	2017
Dr Vinciane Saint-Criq Dr Michael Gray	Role of CFTR in epithelial physiology	2017
Dr Iram Haq Dr Michael Gray Dr James Garnett Professor Christopher Ward Dr Malcolm Brodlie et al.	Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets	2016
Dr Michael Gray Dr Zoltan Rakonczay	CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis	2016
Mark Turner Dr Vinciane Saint-Criq Waseema Patel Salam Ibrahim Dr Burns Verdon et al.	Hypercapnia Modulates cAMP Signalling and Cystic Fibrosis Transmembrane Conductance Regulator-dependent Anion and Fluid Secretion in Airway Epithelia	2016
Abi Marklew Dr Michael Gray	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor	2016
Dr James Garnett Dr Michael Gray Dr Malcolm Brodlie Professor Christopher Ward	Airway epithelial cells secrete bicarbonate in response to acidic by-products of pseudomonas aeruginosa metabolism	2015
Dr Zoltan Rakonczay Viktoria Venglovecz Dr Michael Gray	Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis	2015
Viktoria Venglovecz Dr Zoltan Rakonczay Dr Michael Gray	Potassium channels in pancreatic duct epithelial cells: their role, function and pathophysiological relevance	2015
Dr Steven Broadbent Professor Barry Argent Dr Michael Gray	The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor	2015
Dr Michael Gray	CFTR Loss of Function After Alcohol Consumption and in Alcoholic Pancreatitis	2014
Dr Zoltan Rakonczay Dr Michael Gray Viktoria Venglovecz	Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation	2014
Abi Marklew Dr Michael Gray	Exploring the Mechanisms Behind Cigarette Smoke-induced Internalization of CFTR	2014
Dr Michael Gray Professor John Robinson Dr Jane Falconer	The role of cystic fibrosis transmembrane conductance regulator in antigen processing and presentation to CD4+T-cells	2014
Viktoria Venglovecz Dr Michael Gray Dr Zoltan Rakonczay	The Role of Pancreatic Ductal Secretion in Protection Against Acute Pancreatitis in Mice	2014
Dr James Garnett Dr Michael Gray Dr Malcolm Brodlie Professor Christopher Ward Erin Baker et al.	Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth	2013
Viktoria Venglovecz Dr Zoltan Rakonczay Dr Michael Gray	Ethanol and Its Non-Oxidative Metabolites Profoundly Inhibit CFTR Function in Pancreatic Epithelial Cells Which is Prevented by ATP Supplementation	2013
Dr James Garnett Hui Tunkamnerdthai Dr Michael Gray	Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO₃- secretion by reciprocal regulation of apical and basolateral membrane Cl--HCO₃- exchangers	2013
Dr Michael Gray	Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca2+ Release	2012
Dr John Winpenny Dr Michael Gray	The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age	2012
Dr Michael Gray	Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells	2011
Dr Michael Gray	How to measure CFTR-dependent bicarbonate transport: from single channels to the intact epithelium	2011
Dr Lee Borthwick Phil Botha Dr Malcolm Brodlie Aaron Gardner Dr David Bourn et al.	Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?	2011
Dr James Garnett Dr Michael Gray	Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-expressing Airway Serous Cells	2011
Viktoria Venglovecz Dr Zoltan Rakonczay Dr Michael Gray	Pathophysiological relevance of apical large-conductance Ca²⁺ -activated potassium channels in pancreatic duct epithelial cells	2011
Dr Zoltan Rakonczay Dr Michael Gray Professor Barry Argent Viktoria Venglovecz	Substance P Inhibits Pancreatic Ductal Bicarbonate Secretion via Neurokinin Receptors 2 and 3 in the Guinea Pig Exocrine Pancreas	2011
Viktoria Venglovecz Dr Zoltan Rakonczay Dr Michael Gray Professor Barry Argent	Trypsin Reduces Pancreatic Ductal Bicarbonate Secretion by Inhibiting CFTR Cl- Channels and Luminal Anion Exchangers	2011
Dr Michael Gray	CFTR is a mechanosensitive anion channel: a real stretch?	2010
Viktoria Venglovecz Dr Michael Gray	Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl^-]_i and Its Role in Pancreatic Bicarbonate Secretion	2010
Dr Malcolm Brodlie Dr Michael McKean Dr John Perry Dr Burns Verdon Dr Michael Gray et al.	Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs	2010
Dr Zoltan Rakonczay Viktoria Venglovecz Professor Barry Argent Dr Michael Gray	[Meeting Abstract] The Role of CFTR in the Stimulatory Effect of Chenodeoxycholate on Apical Anion Exchange Activity of Human Pancreatic Duct Cells	2009
John Linley Dr Stefan Boese Professor Nicholas Simmons Dr Michael Gray	A Voltage-Dependent Ca2+ Influx Pathway Regulates the Ca2+-Dependent Cl- Conductance of Renal IMCD-3 Cells	2009
Viktoria Venglovecz Dr Georgina Carr Professor Barry Argent Dr Michael Gray Dr Zoltan Rakonczay et al.	CFTR Expression But Not Cl- Transport Is Involved in the Stimulatory Effect of Bile Acids on Apical Cl-/HCO3- Exchange Activity in Human Pancreatic Duct Cells	2009
Viktoria Venglovecz Dr Zoltan Rakonczay Professor Barry Argent Dr Michael Gray	Chenodeoxycholate Activates Ion Channels in Guinea Pig Pancreatic Duct Cells	2009
Dr Michael Gray	Inhibition of Protein Kinase CK2 Closes the CFTR Cl- Channel, but has no Effect on the Cystic Fibrosis Mutant Delta F508-CFTR CFTR	2009
Dr Michael Gray	Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide	2009
Dr Zoltan Rakonczay Professor Barry Argent Dr Michael Gray	CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector.	2008
Dr Zoltan Rakonczay Viktoria Venglovecz Dr Michael Gray Professor Barry Argent	Controversies in the role of SLC26 anion exchangers in pancreatic ductal bicarbonate secretion	2008
Viktoria Venglovecz Dr Zoltan Rakonczay Dr Michael Gray Professor Barry Argent	Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig	2008
John Linley Professor Nicholas Simmons Dr Michael Gray	Extracellular zinc stimulates a calcium-activated chloride conductance through mobilisation of intracellular calcium in renal inner medullary collecting duct cells	2007
Dr Michael Gray	Orchestration of vectorial chloride transport by epithelia	2007
Dr Burns Verdon Professor Barry Argent Dr Michael Gray	Sendai virus-mediated CFTR gene transfer to the airway epithelium	2007
Professor Barry Argent Dr Michael Gray	Cell physiology of pancreatic ducts	2006
Dr Zoltan Rakonczay Professor Barry Argent Dr Michael Gray	CFTR gene transfer to human cystic fibrosis pancreatic duct cells upregulates apical CL-/HCO3(-) exchange activity	2006
Dr Zoltan Rakonczay Dr Amy Fearn Dr Michael Gray Professor Barry Argent	Characterization of H+ and HCO3- transporters in CFPAC-1 human pancreatic duct cells	2006
Dr Michael Gray Professor Barry Argent	Discussion	2006
Dr Michael Gray	Discussion	2006
Dr Michael Gray Professor Barry Argent	Discussion	2006
Dr Michael Gray	Discussion	2006
Dr Michael Gray	Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo	2006
Dr Michael Gray	Orchestration of Vectorial Chloride Transport by Epithelia	2006
Dr Michael Gray	Primary cilia and regulation of renal Na+ transport. Focus on "Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia"	2006
Dr Zoltan Rakonczay Dr Michael Gray Professor Barry Argent	SLC26 transporters and the inhibitory control of pancreatic ductal bicarbonate secretion	2006
Dr Michael Gray	The physiology of anion transport: Tales of the bizarre and unexpected	2006
Dr Zoltan Rakonczay Dr Amy Fearn Dr Michael Gray Professor Barry Argent	Characterization of H⁺ and HCO₃^- transporters in CFPAC-1 human pancreatic duct cells	2005
Dr Michael Gray Professor Barry Argent	Effect of herpesvirus infection on pancreatic duct cell secretion	2005
Dr Zoltan Rakonczay Dr Michael Gray Professor Barry Argent	Protein kinase C mediates the inhibitory effect of substance P on HCO 3- secretion from guinea pig pancreatic ducts	2005
Dr Stefan Boese Dr Michael Gray Professor Nicholas Simmons	Volume-dependent and -independent activated anion conductances and their interaction in the renal inner medullary collecting duct (IMCD)	2005
Dr Zoltan Rakonczay Dr Amy Fearn Dr Michael Gray Professor Barry Argent	A novel basolateral bicarbonate transport mechanism in human pancreatic duct cells	2004
Dr Michael Gray	Bicarbonate secretion: It takes two to tango	2004
Professor Barry Argent Dr Michael Gray	Identification of pancreatic K+ channels mediating ATP-stimulated Cl- secretion	2004
Dr Stefan Boese Omar Aziz Professor Nicholas Simmons Dr Michael Gray	Kinetics and regulation of a Ca²⁺-activated Cl^- conductance in mouse renal inner medullary collecting duct cells	2004
Dr Zoltan Rakonczay Dr Michael Gray Professor Barry Argent	Measurement of Intracellular pH in Pancreatic Duct Cells: A New Method for Calibrating the Fluorescence Data	2004
Dr Michael Gray Professor Barry Argent	Murine epithelial cells: Isolation and culture	2004
Professor Barry Argent Dr Michael Gray	Novel regulation of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by external chloride	2004
Dr Michael Gray Professor Barry Argent	Recombinant sendai virus mediates CFTR gene transfer to airway epithelium both in vitro and in vivo	2004
Dr Michael Gray	The patch-clamp and planar lipid bilayer techniques: Powerful and versatile tools to investigate the CFTR Cl- channel	2004
Dr Phillip Aldridge Dr Michael Gray Emeritus Professor Barry Hirst Dr Anjam Khan	Who's talking to whom? Epithelial-bacterial pathogen interactions	2004
Professor Barry Argent Dr Michael Gray	Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF	2003
Dr Michael Gray Omar Aziz Professor Nicholas Simmons Dr Stefan Boese	Intracellular Ca2+ directly regulates the Ca2+ activated Cl conductance in mouse inner medullary collecting duct cells	2003
Dr Stefan Boese Omar Aziz Professor Nicholas Simmons Dr Michael Gray	Intracellular Ca2+ directly regulates the Ca2+-activated Cl- conductance in mouse inner medullary collecting duct cells	2003
Professor Barry Argent Dr Michael Gray	Molecular & functional analysis of Cl- and K+ channels in HPAF cells	2003
Dr Michael Gray	Recombinant Sendai virus mediates CFTR gene transfer to airway epithelium both ex vivo and in vivo	2003
Dr Michael Gray Professor Barry Argent	Recombinant Sendai virus-mediated CFTR cDNA transfer	2003
Professor Barry Argent Dr Michael Gray	Regulation of CFTR by extracellular anions is modulated by cytosolic calcium and phosphatase activity	2003
Dr Michael Gray Professor Barry Argent	Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger	2003
Dr Michael Gray Professor Barry Argent	Substance P inhibits bicarbonate secretion in guinea pig panceatic ducts by modulating an anion exchanger	2003
Dr Michael Gray	Designer pharmacotherapy for the treatment of cystic fibrosis	2002
Dr Michael Gray	Designer pharmacotherapy for the treatment of cystic fibrosis: Commentary on Zegarra-Moran et al	2002
Dr Michael Gray Dr John Winpenny Professor Barry Argent	Properties and role of calcium-activated chloride channels in pancreatic duct cells	2002
Dr Michael Gray Dr John Winpenny Dr Catherine O'Reilly Professor Barry Argent	Properties and role of calcium-activated chloride channels in pancreatic duct cells	2002
Dr Michael Gray Professor Barry Argent	Regulation of murine airway surface liquid volume by CFTR and Ca2+-activated Cl- conductances	2002
Dr Stefan Boese Professor John Sayer Dr Gavin Stewart Dr Michael Glanville Dr Michael Gray et al.	Renal expression of Ca2+-activated Cl- channels	2002
Dr Stefan Boese Professor John Sayer Dr Gavin Stewart Dr Michael Glanville Dr Michael Gray et al.	Renal expression of Ca2+-activated Cl- channels	2002
Dr Michael Gray Omar Aziz	Role of capacitative calcium entry in secretion by A549 epithelial cells [abstract]	2002
Dr Michael Gray Professor Barry Argent	150 mM HCO₃^- - How does the pancreas do it? Clues from computer modelling of the duct cell	2001
Dr Michael Gray	Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells	2001
Dr Michael Gray Dr Catherine O'Reilly Dr John Winpenny Professor Barry Argent	Functional interactions of HCO3- with cystic fibrosis transmembrane conductance regulator	2001
Dr Michael Gray Omar Aziz	Multiple calcium entry pathways in A549 alveolar type II epithelial cells	2001
Dr Gavin Stewart Omar Aziz Professor Nicholas Simmons Dr Michael Gray	Regulation of an outwardly rectifying chloride conductance in renal epithelial cells by external and internal calcium	2001
Professor John Sayer Dr Gavin Stewart Dr Stefan Boese Dr Michael Gray Professor Simon Pearce et al.	The voltage-dependent of Cl- channel ClC-5 and plasma membrane Cl- conductances of mouse renal collecting duct cells (mIMCD-3)	2001
Dr Michael Gray Dr Catherine O'Reilly Dr John Winpenny Professor Barry Argent	Anion interactions with CFTR and consequences for HCO3- transport in secretory epithelia	2000
Dr Michael Gray Dr Colin Brown Professor Nicholas Simmons	Bradykinin regulation of salt transport across mouse inner medullary collecting duct epithelium involves activation of a Ca2+ -dependent Cl- conductance	2000
Dr Stefan Boese Dr Michael Glanville Omar Aziz Dr Michael Gray Professor Nicholas Simmons et al.	Ca2+ and cAMP-activated Cl- conductances mediate Cl- secretion in a mouse renal inner medullary collecting duct cell line	2000
Dr Catherine O'Reilly Dr John Winpenny Professor Barry Argent Dr Michael Gray	Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: Inhibition by bicarbonate ions	2000
Dr Catherine O'Reilly Dr John Winpenny Professor Barry Argent Dr Michael Gray	Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: inhibition by bicarbonate ions	2000
Professor Barry Argent Dr Michael Gray	Regulation of a hyperpolarization-activated chloride current in murine respiratory ciliated cells	2000
Dr Stefan Boese Dr Michael Glanville Dr Michael Gray Professor Nicholas Simmons	The swelling-activated anion conductance in the mouse renal inner medullary collecting duct cell line mIMCD-K2	2000
Jeanette Adair Darren Stephenson Dr Michael Gray Professor Barry Argent	Anion secretion and intracellular calcium concentration in a human pancreatic duct cell line (HPAF)	1999
Dr Stefan Boese Professor Nicholas Simmons Dr Michael Gray	ATP and forskolin stimulate transepithelial Cl- secretion in mouse renal inner medullary collecting duct cells (mIMCD-K2) by activation of distinct Cl- conductances	1999
Dr Gavin Stewart Dr Michael Glanville Dr Michael Gray Professor Nicholas Simmons	ATP stimulates a chloride conductance in the mIMCD-3 cell line	1999
Jeanette Adair Professor Barry Argent Dr Michael Gray	ATP-induced [CA2+]i oscillations in a human pancreatic duct cell line (HPAF)	1999
Dr Michael Gray Professor Barry Argent	Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel	1999
Dr Michael Gray Professor Barry Argent	Novel activators of CFTR in native epithelial cells	1999
Professor Barry Argent Dr Michael Gray	Substituted benzoquinolizinium compounds activate CFTR in native pancreatic duct cells	1999
Dr Stefan Boese Dr Michael Glanville Professor Nicholas Simmons Dr Michael Gray	The swelling-activated chloride conductance in mIMCD-K2 cells is associated with multiple CLC expression.	1999