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Lookup NU author(s): James Dyson, Professor Kenneth Dalgarno
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Currently there is no adequate bone replacement available that combines a long implant life with complete integration and appropriate mechanical properties. This paper reports on the use of human mesenchymal stem cells (MSCs) to populate porous bioceramic scaffolds produced by selective laser sintering (SLS) to create bespoke bioactive bone replacement structures. Apatite-wollastonite glass ceramic was chosen for use in this study because of its combination of excellent mechanical and biological properties, and has been processed using an indirect SLS approach. Process maps have been developed to identify process conditions for the SLS stage of manufacture and an optimised furnace cycle for the material has been developed to ensure that the required material phases for bioactivity are present in the manufactured scaffold. Results from tissue culture with the MSCs on the scaffolds (using confocal and scanning electron microscopy) show that MSCs adhere, spread and retain viability on the surface, and penetrate into the pores of apatite wollastonite (A-W) glass ceramic scaffolds over a 21 day culture period. The MSCs also show strong indications of osteogenesis, indicating that the MSCs are differentiating to osteoblasts. These resultsindicate good biocompatibility and osteo supportive capacity of SLS generated A-W scaffolds and excellent potential in bone replacement applications. Copyright © 2007 by ASME.
Author(s): Xiao K, Dyson JA, Dalgarno KW, Genever P, Wood DJ, Goodridge RD, Ohtsuki C
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Proceedings of the ASME International Manufacturing Science and Engineering Conference 2007, MSEC2007
Year of Conference: 2007
Pages: 83-90
Publisher: American Society of Mechanical Engineers
URL: http://dx.doi.org/10.1115/MSEC2007-31031
DOI: 10.1115/MSEC2007-31031
Library holdings: Search Newcastle University Library for this item
ISBN: 0791842908
