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Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation

Lookup NU author(s): Professor Andrew FisherORCiD, Professor Kate Gould, Dr James Lordan, Professor John Dark, Emeritus Professor Nick Europe-Finner

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Abstract

Pseudomembranous colitis is an uncommon complication in patients with cystic fibrosis, despite the use of multiple high-dose antibiotic regimens and the frequency of hospital admissions. Four patients from a total or 137 patients with cystic fibrosis undergoing lung transplantation are described who developed fulminant pseudomembranous colitis. Initial presentation was variable and me mortality rate was 50% despite urgent colectomy. In one case the presenting abdominal distension was thought to be due to meconium ileus equivalent. It is concluded that Clostridium difficile colitis may be a difficult diagnosis in patients with cystic fibrosis and follows a fulminant course after lung transplantation.

Publication metadata

Author(s): Yates B, Murphy DM, Fisher AJ, Gould FK, Lordan JL, Dark JH, Corris PA

Publication type: Article

Publication status: Published

Journal: Thorax

Year: 2007

Volume: 62

Issue: 6

Pages: 554-556

Print publication date: 01/06/2007

Date deposited: 24/05/2010

ISSN (print): 0040-6376

ISSN (electronic): 1468-3296

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/thx.2005.048652

DOI: 10.1136/thx.2005.048652

PubMed id: 16601087

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