Publications by Dr James Lordan - ePrints

Browsing publications by Dr James Lordan.

Newcastle Authors	Title	Year
Dr James Lordan	Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension	2024
Dr James Lordan	Oral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension	2024
Dr James Lordan	Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood (Nature Communications, (2021), 12, 1, (7104), 10.1038/s41467-021-27326-0)	2022
David Stephenson Dr Daniela Lee Jill Davison Dr Stephen Bourke Professor Anthony De Soyza et al.	An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation	2019
Professor Andrew Fisher Dr James Lordan Dr Gerard Meachery Dr Bart Vanaudenaerde	An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe	2017
Dr Zheyi Liew Professor Kate Gould Dr Su Bunn Dr Matthew Thomas Dr James Lordan et al.	Successful outcome following pneumonectomy in a teenage boy with cystic fibrosis: a case report.	2017
Dr James Lordan	Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy: Results From the United Kingdom National Cohort	2016
Dr Logan Thirugnanasothy Sasiharan Sithamparanathan Dr James Lordan Professor Andrew Fisher Dr Guy MacGowan et al.	Establishing The Effect Of Targeted Therapies On Diffusing Capacity In Patients With Pulmonary Arterial Hypertension (PAH)	2016
Sasiharan Sithamparanathan Dr Logan Thirugnanasothy Professor John Dark Professor Andrew Fisher Professor Kate Gould et al.	Observational study of lung transplant recipients surviving 20 years	2016
Sasiharan Sithamparanathan Dr Logan Thirugnanasothy Professor Andrew Fisher Dr James Lordan Dr Gerard Meachery et al.	Observational Study of Methotrexate in the Treatment of Bronchiolitis Obliterans Syndrome	2016
Dr Gareth Parry Professor Andrew Fisher Dr Gerard Meachery Dr James Lordan	Total Lymphoid Irradiation (TLI) for the Management of Bronchiolitis Obliterans Syndrome (BOS) Post Lung Transplant: A Single Centre Experience	2016
Vicky Ryan Therese Small Dr James Lordan Professor Andrew Fisher Dr Gerard Meachery et al.	A randomised controlled trial of azithromycin therapy in Bronchiolitis Obliterans Syndrome (BOS) post lung transplantation	2015
Professor Anthony De Soyza Dr James Lordan Professor Jeffrey Pearson Professor Christopher Ward	Azithromycin Attenuates Release Of Bile Acid-Mediated Neutrophilic And Remodeling Factors From Human Bronchial Epithelial Cells	2015
Professor Anthony De Soyza Dr James Lordan June Pearson Professor Christopher Ward	Azithromycin Attenuates Release of Bile Acid-Mediated Neutrophilic and Remodelling Factors from Human Bronchial Epithelial Cells	2015
Professor Anthony De Soyza Dr James Lordan Professor Jeffrey Pearson Professor Christopher Ward	Bile Acids Cause Direct Inflammation And Injury And Worsen Acid Induced Injury In The Pulmonary Epithelium	2015
Professor Anthony De Soyza Dr James Lordan Professor Jeffrey Pearson Professor Christopher Ward	Bile Acids Cause Direct Inflammation and Injury and Worsen Acid Induced Injury in the Pulmonary Epithelium	2015
Sasiharan Sithamparanathan Dr Logan Thirugnanasothy Professor Andrew Fisher Dr James Lordan Dr Gerard Meachery et al.	A Retrospective Observational Study of 20 Year Lung Transplant Survivors - A Single Centre Experience	2014
Dr Ali Anwar Professor Anthony De Soyza Dr Sylvia Worthy Dr James Lordan Professor Christopher Ward et al.	Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis	2014
Dr James Lordan Dr Gerard Meachery Professor Andrew Fisher Dr Gareth Parry	Pregnancy after lung and heart-lung transplantation	2014
Dr James Lordan Professor Andrew Fisher Dr Bart Vanaudenaerde	The Impact of Air Pollution on Outcome After Lung Transplantation in Europe	2014
Dr Sarah Woolcock Professor Andrew Fisher Dr James Lordan Dr Guy MacGowan	The Role of Specialist Palliative Care Services in the Management of Patients with Pulmonary Arterial Hypertension; A Review of Current Practice	2014
Stephen Clark Professor Andrew Fisher Dr James Lordan Dr Gerard Meachery Dr Gareth Parry et al.	Improving Outcomes in Lung Transplantation for Cystic Fibrosis - A Unified Approach	2013
Dr Ali Anwar Dr Sylvia Worthy Professor Stephen Bourke Dr James Lordan Professor Anthony De Soyza et al.	Phenotyping adults with non-cystic fibrosis bronchiectasis: A prospective observational cohort study	2013
Dr James Lordan Dr Gerard Meachery Professor Andrew Fisher Dr Gareth Parry	Pregnancy after Lung Transplantation: A Single Center Experience	2013
Therese Small Professor Andrew Fisher Dr James Lordan	Treatment Outcomes in Pulmonary Arterial Hypertension (PHA) Associated with Systemic Sclerosis (Sscl.) in Matched Groups Using Either Bosentan or Sildenafil Monotherapy	2013
Therese Small Vicky Ryan Dr James Lordan Professor Andrew Fisher Dr Gerard Meachery et al.	A Randomised Controlled Trial of Azithromycin Therapy in Bronchiolitis Obliterans Syndrome (BOS) Post Lung Transplantation	2012
Ali Aseeri Dr Malcolm Brodlie Dr James Lordan Professor Jeffrey Pearson Professor Christopher Ward et al.	Bile Acids Are Present in the Lower Airways of People with Cystic Fibrosis	2012
Dr Joaquim Majo Dr Rahul Mahida Dr Neelima Thampy Dr Fiona Black Dr Gerard Meachery et al.	Prospective Evaluation of Alveolar and Bronchiolar C4d Expression in Transbronchial Biopsies from Lung Transplanted Recipients	2012
Dr Malcolm Brodlie Dr James Lordan Professor Christopher Ward	Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?	2011
Dr Malcolm Brodlie Dr James Lordan Professor Christopher Ward	Ceramide and cystic fibrosis lung disease	2011
Professor Andrew Fisher Professor Kate Gould Dr Gerard Meachery Dr James Lordan	Cystic fibrosis, lung transplantation and clostridium difficile associated disease	2011
Dr Venetia Bigley Professor Muzlifah Haniffa Dr Xiao Wang Dr Rachel Dickinson Dr Naomi McGovern et al.	Dendritic cell, monocyte, B and NK lymphoid deficiency: a novel but potentially fatal haematological disorder curable with haematopoietic stem cell transplantation	2011
Dr Malcolm Brodlie Dr Michael McKean Dr Amy Anderson Professor Catharien Hilkens Professor Andrew Fisher et al.	Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease	2011
Dr Katherine Sturgess Professor Mary Slatter Dr Venetia Bigley Professor Muzlifah Haniffa Dr Xiao Wang et al.	Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation	2011
Dr Gerard Meachery Anne Nicholson Dr James Lordan Professor Andrew Fisher Professor Kate Gould et al.	Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas Aeruginosa	2011
Dr James Lordan Professor Andrew Fisher Dr Guy MacGowan	Ten Year Survival in Incident Cases of Idiopathic Pulmonary Arterial Hypertension (IPAH) in the Modern Era	2011
Dr Katy Hester Dr Sarah Wiscombe Dr Gareth Parry Dr Gerard Meachery Professor Anthony De Soyza et al.	The impact of BMI on survival of patients with cystic fibrosis undergoing lung transplantation: a single centre experience	2011
Dr Andrew Robertson Professor Christopher Ward Therese Small Dr James Lordan Professor Andrew Fisher et al.	Longitudinal changes in gastro-oesophageal reflux from three months to six months post lung transplantation	2010
Dr Malcolm Brodlie Dr Michael McKean Dr John Perry Dr Burns Verdon Dr Michael Gray et al.	Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs	2010
Dr Venetia Bigley Dr Clare Morgan Professor Matthew Collin Dr James Lordan	Pulmonary alveolar proteinosis due to monocytopenia: lung transplant or haematopoeitic stem cell transplant? [abstract]	2010
Dr James Lordan	The varied presentation and complications of pulmonary vasculitis: a single centre experience [abstract]	2010
Dr Andrew Robertson Professor Christopher Ward Professor Jeffrey Pearson Professor Andrew Fisher Dr James Lordan et al.	Aspiration Secondary to Gastro-Oesophageal Reflux but not Duodenal Reflux Occurs in the Immediate Post Lung Transplantation Period	2009
Dr Ian Forrest Professor Christopher Ward Vicky Ryan Dr Gavin Johnson Dr James Lordan et al.	Bronchalveolar Lavage Neutrophilia and MMP-9 at 3 Months Post Lung Transplantation May Predict the Development of BOS	2009
Dr Malcolm Brodlie Dr Michael McKean Professor Andrew Fisher Dr James Lordan Professor Christopher Ward et al.	Ceramide is increased and associated with neutrophilic inflammation in the lower airway epithelium of people with cystic fibrosis	2009
Dr Lee Borthwick Dr Sean Parker Kate Brougham Marta Gorowiec Professor Christopher Ward et al.	Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation	2009
Dr Lee Borthwick Dr Malcolm Brodlie Professor Christopher Ward Dr James Lordan Emeritus Professor John Kirby et al.	Pro-inflammatory Cytokines IL-1 beta and TNT alpha, but Not IL-8, Cause Aberrant Lung Epithelial Wound Repair Via TGF-beta 1 Driven Epithelial to Mesenchymal Transition (EMT)	2009
Dr Malcolm Brodlie Dr Michael McKean Professor Andrew Fisher Dr James Lordan Professor Christopher Ward et al.	Reticular basement membrane thickening in end-stage cystic fibrosis lung disease	2009
Rachel Stovold Dr Ian Forrest Dr James Lordan Professor Andrew Fisher Professor John Dark et al.	Temporal Patterns of Lung Pepsin Levels in Allografts Suggest Aspiration Is an Ongoing Injury, Which Can Occur Early Following Lung Transplantation	2009
Dr Sean Parker Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Dr Gabriele Saretzki et al.	Airway epithelial cell senescence in the lung allograft	2008
Dr Rachel Anderson Professor Christopher Ward Dr Ian Forrest Dr James Lordan Professor Andrew Fisher et al.	Antimicrobial Peptides in Lung Transplant Recipients with Bronchiolitis Obliterans Syndrome	2008
Adillah Binti Yusof Dr Ian Forrest Therese Small Debra Jones Professor Andrew Fisher et al.	Azithromycin attenuates effects of lipopolysaccharide on lung allograft bronchial epithelial cells	2008
Dr Ian Forrest Dr Gavin Johnson Therese Small Professor Andrew Fisher Emeritus Professor Tim Cawston et al.	Azithromycin attenuates lipopolysaccharide-mediated release of interleukin-8 and GM-CSF from primary bronchial epithelial cells derived from stable lung transplant recipients	2008
Rachel Stovold Professor Andrew Fisher Dr James Lordan Professor Jeffrey Pearson Professor Christopher Ward et al.	Does pepsin in gastric juice aspirated into the lung allograft stimulate mucus hypersecretion?	2008
Rachel Stovold Dr Ian Forrest Dr James Lordan Professor Andrew Fisher Professor Jeffrey Pearson et al.	Longitudinal assessment of pepsin levels in lung allografts suggests aspiration is an ongoing injury, which can occur early following lung transplantation	2008
Marta Gorowiec Dr Lee Borthwick Marcin Pekalski Dr James Lordan Professor Christopher Ward et al.	Oxidative stress induces epithelial to mesenchymal transition in human lung epithelial cells through transforming groeth factor beta and integrin beta6-dependent mechanism	2008
Dr Lee Borthwick Kate Brougham Professor Christopher Ward Dr James Lordan Emeritus Professor John Kirby et al.	Pro-inflammatory cytokines dysregulate lung epithelial wound repair via epithelial to mesenchymal transition	2008
Phil Botha Dr Rachel Anderson Dr James Lordan Professor John Dark Katherine Gould et al.	Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome	2008
Dr Andrew Robertson Professor Michael Griffin Professor Christopher Ward Professor Jeffrey Pearson Anne Bredenoord et al.	Qualitative and quantitative assessments of aspiration in the immediate post-lung transplantation period	2008
Emeritus Professor Mike Sir Michael Rawlins Dr Ian Forrest Therese Small Debra Jones Professor Andrew Fisher et al.	Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients	2008
Dr Malcolm Brodlie Dr Michael McKean Dr John Perry Anne Nicholson Professor Jeffrey Pearson et al.	The culture of primary bronchial epithelial cells from the lungs of people with cystic fibrosis removed at the time of transplantation: a model to study cystic fibrosis lung disease	2008
Dr Joaquim Majo Dr Sean Parker Dr Fiona Black Dr James Lordan Professor Andrew Fisher et al.	The role of trausbronchial biopsies in the diagnosis of obliterative bronchiolitis: Time for a re-evaluation?	2008
Dr Lee Borthwick Sally Maloney Dr Rachel Anderson Professor Christopher Ward Dr James Lordan et al.	Transforming growth factor beta 1 suppresses secretory leucoprotease inhibitor release in response to infection in lung epithelial cells	2008
Dr Lee Borthwick Dr Sean Parker Marta Gorowiec Professor Christopher Ward Dr James Lordan et al.	Tumour necrosis factor-α accentuates transforming growth factor-β driven epithelial to mesenchymal transition (EMT) in airway epithelial cells from lung transplant recipients	2008
Dr Laura Mackay Professor Christopher Ward Dr James Lordan Professor Andrew Fisher	Alveolar septae in severe end-stage emphysema show morphological evidence of dysregulated mesenchymal cell proliferation and loss of microvascularity	2007
Dr Laura Mackay Dr Guy MacGowan Professor Andrew Fisher Dr James Lordan	Correlation of NT-probrain natriuretic peptide (NTproBNP) and haemodynamics, in patients with pulmonary arterial hypertension (PAH)	2007
Dr Ian Forrest Professor Christopher Ward Debra Jones Professor Andrew Fisher Emeritus Professor Tim Cawston et al.	Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts	2007
Marta Gorowiec Dr Sean Parker Dr Lee Borthwick Professor Christopher Ward Dr James Lordan et al.	Oxidative stress increases transforming growth factor-beta expression and drives epithelial to mesenchymal transition in human lung epithelial cells	2007
Professor Andrew Fisher Professor Kate Gould Dr James Lordan Professor John Dark	Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation	2007
Dr Laura Mackay Dr Rachel Anderson Dr James Lordan Professor Andrew Fisher	Pulmonary fibrosis: Rate of disease progression as a trigger for referral for lung transplantation	2007
Dr Sean Parker Professor Christopher Ward Dr James Lordan Dr Gabriele Saretzki Professor Andrew Fisher et al.	Stress-induced premature senescence in airway epithelium and accelerated lung allograft aging	2007
Dr Gerard Meachery Professor Anthony De Soyza Dr James Lordan Professor Kate Gould Professor John Dark et al.	Survival outcomes following lung transplantation for cystic fibrosis patients infected with burkholderia cenocepacia - A UK experience	2007
Dr Rachel Anderson Dr Lee Borthwick Dr James Lordan Professor Andrew Fisher	The effect of calcineurin inhibitors (CNI) on the release of secretory leucoproteinase inhibitor (SLPI) by lung epithelial cells in the presence of transforming growth factor-beta (TGF-beta)	2007
Dr Sean Parker Marta Gorowiec Dr Lee Borthwick Dr James Lordan Professor Christopher Ward et al.	Transforming growth factor beta (TGF beta) induces cellular senescence in primary bronchial epithelial cells: A possible role in airway remodelling	2007
Professor Kate Gould Professor Andrew Fisher Dr James Lordan Professor John Dark	Twenty six years experience of lymphoproliferative disease following lung transplantation (PTLD)	2007
Dr Rachel Anderson Dr Ian Forrest Dr James Lordan Professor Andrew Fisher	Antimicrobial peptides and airway innate immunity in the pathophysiology of bronchiolitis obliterans syndrome (BOS) after lung transplantation	2006
Dr Neil Archibald Dr Fiona Black Dr James Lordan Professor John Dark	Carbamazepine-induced interstitial pneumonitis in a lung transplant patient	2006
Phil Botha Dr Rachel Anderson Dr James Lordan Professor John Dark Professor Kate Gould et al.	Colonization of lung transplant recipients with Pseudomonas Aeruginosa and the development of bronchiolitis obliterans syndrome.	2006
Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Professor Andrew Fisher	Epithelial mesencymal transition occurs in primary airway epithelial cells in response to transforming growth factor-beta and epidermal growth factor	2006
Dr James Lordan Professor Andrew Fisher	Factors affecting suitability of patients for lung transplantation assessment in a cohort referred to a single centre 2000-05	2006
Dr Ian Forrest Professor Christopher Ward Dr Desmond Murphy David Jones Dr James Lordan et al.	Hepatocyte growth factor - A link between neutrophilic inflammation and BOS?	2006
Dr Laura Mackay Therese Small Dr James Lordan Professor Andrew Fisher	Long term administration of intravenous (IV) Iloprost for pulmonary arterial hypertension	2006
Dr Lee Borthwick Dr Sean Parker Professor Christopher Ward Dr James Lordan Professor Andrew Fisher et al.	Oxidative stress induces epithelial to mesenchymal transition in bronchial epithelial cells: A possible role in airway remodelling	2006
Dr Sean Parker Professor Christopher Ward Dr Fiona Black Dr James Lordan Dr Gabriele Saretzki et al.	Premature senescence of airway epithelial cells: A possible role in airway remodelling after human lung transplantation	2006
Dr Rachel Anderson Dr James Lordan Professor Andrew Fisher	The antimicrobial peptide, human beta defensin-2, in acute rejection after human lung transplantation	2006
Dr Rachel Anderson Dr Lee Borthwick Dr James Lordan Professor Andrew Fisher	The effect of immunosuppressants on secretory leucoproteinase inhibitor production by lung epithelium in the presence of transforming growth factor-beta	2006
Professor Christopher Ward Dr Ian Forrest Professor David Jones Dr Gary Pritchard Rachel Stovold et al.	The phosphodiesterase type IV (PDE IV) inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells derived from lung transplant recipients	2006
Dr Desmond Murphy Professor Christopher Ward David Jones Rachel Stovold Professor Andrew Fisher et al.	The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients	2006
Phil Botha Dr Rachel Anderson Dr James Lordan Professor John Dark Professor Kate Gould et al.	The role of primary graft dysfunction or recurrent acute rejection episodes in the development of Pseudomonas colonisation after lung transplantation	2006
Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Professor Andrew Fisher	Tumour necrosis factor-alpha accentuates transforming growth factor-beta driven epithelial to mesenchymal transition in lung epithelial cells	2006
Dr Rodney Bexton Dr Chris Plummer Professor John Dark Dr Fiona Black Dr James Lordan et al.	Aortic regurgitation and Churg-Strauss syndrome	2005
Professor Christopher Ward Dr Robert Rutherford Professor Andrew Fisher Dr James Lordan Professor John Dark et al.	Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome	2005
Professor Christopher Ward Dr Ian Forrest Professor Andrew Fisher Dr James Lordan	Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome (BOS) following lung transplantation	2005
Dr Ian Forrest Dr James Lordan Dr Gary Pritchard Professor David Jones Dr Helen Robertson et al.	Epithelial to mesenchymal transition in clinically stable lung transplant recipients	2005
Crispian Oates Dr James Lordan	Evidence for systemic endothelial dysfunction in patients and first-order relatives with pulmonary arterial hypertension	2005
Dr Laura Mackay Dr Rachel Anderson Dr James Lordan Professor John Dark Professor Andrew Fisher et al.	Factors influencing success of achieving lung transplantation in patients with pulmonary fibrosis placed on the waiting list 1999-2004	2005
Professor Christopher Ward Dr Helen Robertson Dr Ian Forrest Dr James Lordan Denis Murphy et al.	Hypothesis: Epithelial-to-mesenchymal transition is a common cause of chronic allograft failure	2005
Professor Christopher Ward Dr Ian Forrest Dr Helen Robertson Emeritus Professor Tim Cawston Professor Andrew Fisher et al.	Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients	2005
Dr Ian Forrest Dr Desmond Murphy Professor Christopher Ward David Jones Professor Kate Gould et al.	Primary airway epithelial cell culture from lung transplant recipients	2005
Dr John O'Sullivan Professor Andrew Fisher Dr James Lordan Dr Guy MacGowan	The effect of bosentan on exercise capacity in patients with Eisenmenger's syndrome	2005
Professor Andrew Fisher Dr Robert Rutherford Dr James Lordan	The feasibility of complete withdrawal of oral corticosteroids following lung transplantation	2005
Dr Ian Forrest Professor Christopher Ward Professor Andrew Fisher Emeritus Professor Tim Cawston Dr James Lordan et al.	The potential role of interleukin-17 in airway inflammation and remodelling in post-transplant obliterative bronchiolitis	2005
Professor Bob Anderson Dr Ian Forrest Professor Christopher Ward Dr Gavin Johnson Dr James Lordan et al.	The pulmonary innate immune response to pseudomonas aeruginosa infection in human lung transplant recipients	2005
Dr Ian Forrest Dr James Lordan Dr Helen Robertson Emeritus Professor Tim Cawston Professor John Dark et al.	Epithelial to mesenchymal transition in clinically stable lung transplantation	2004
Dr Ian Forrest Professor Christopher Ward Emeritus Professor Tim Cawston Dr James Lordan	IL-17 stimulates IL-8 release in primary epithelial cell cultures derived from lung allografts	2004
Dr James Lordan Dr Alistair Gascoigne	The pulmonary physician in critical care center dot Illustrative case 7: Assessment and management of massive haemoptysis	2003