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The ageing mitochondrial genome

Lookup NU author(s): Dr Laura Greaves, Dr Amy Reeve, Emeritus Professor Doug Turnbull



The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process. One plausible mechanism for ageing is accumulation of mutations in the mitochondrial genome. In this review, we discuss some of the most convincing data surrounding age-related mtDNA mutations and the evidence that these mutations contribute to the ageing process. © 2007 The Author(s).

Publication metadata

Author(s): Krishnan KJ, Greaves LC, Reeve AK, Turnbull D

Publication type: Review

Publication status: Published

Journal: Nucleic Acids Research

Year: 2007

Volume: 35

Issue: 22

Pages: 7399-7405

Print publication date: 01/12/2007

ISSN (print): 0305-1048

ISSN (electronic): 1362-4954


DOI: 10.1093/nar/gkm635

PubMed id: 17913753