Browse by author
Lookup NU author(s): Dr Stuart Kendrick, Professor Chris Day
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Coffee, cirrhosis and Transaminase enzymes, Klatsky AL, Morton C, Udaltsova N, Friedman GD. Background/Aims: A minority of persons at risk develop liver cirrhosis, but knowledge of risk modulators is sparse. Several reports suggest that coffee drinking is associated with lower cirrhosis risk. Methods: We studied 125,580 multiethnic members of a comprehensive prepaid health care plan without known liver disease who supplied baseline data at voluntary health examinations from 1978 to 1985. Subsequently, through 2001, 330 of them were diagnosed with liver cirrhosis. Review of medical records confirmed the diagnosis of cirrhosis and ascertained probable etiology. The association of coffee drinking with cirrhosis was estimated by Cox proportional hazards models with seven covariates. We also did a cross-sectional analysis of baseline aspartate aminotransferase and alanine aminotransferase levels, studied by logistic regression. Results: In the cohort study, relative risks of alcoholic cirrhosis (199 subjects) for coffee drinking (vs none) were less than 1 cup per day, 0.7 (95% confidence interval [CI], 0.4-1.1); 1-3 cups, 0.6 (95% CI, 0.4-0.8; P < .001); and 4 or more cups, 0.2 (95% CI, 0.1-0.4; P < .001). For 131 subjects with nonalcoholic cirrhosis, relative risks were less than 1 cup, 1.2 (95% CI, 0.6-2.2); 1-3 cups, 1.3 (95% CI, 0.8-2.1); and 4 or more cups, 0.7 (95% CI, 0.4-1.3). These relative risks for coffee drinking were consistent in subsets. Tea drinking was unrelated to alcoholic or nonalcoholic cirrhosis. In the cross-sectional analyses, coffee drinking was related to lower prevalence of high aspartate aminotransferase and alanine aminotransferase levels; for example, the odds ratio of 4 or more cups per day (vs none) for a high aspartate aminotransferase level was 0.5 (95% CI, 0.4-0.6; P < .001) and for a high alanine aminotransferase level, 0.6 (95% CI, 0.6-0.7; P < .001), with stronger inverse relations in those who drink large quantities of alcohol. Conclusions: These data support the hypothesis that there is an ingredient in coffee that protects against cirrhosis, especially alcoholic cirrhosis. [Abstract reproduced by permission of Arch Intern Med 2006;166:1190-1195]. © 2007 European Association for the Study of the Liver.
Author(s): Kendrick SFW, Day CP
Publication type: Article
Publication status: Published
Journal: Journal of Hepatology
Year: 2007
Volume: 46
Issue: 5
Pages: 980-982
ISSN (print): 0168-8278
ISSN (electronic): 1600-0641
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.jhep.2007.02.004
DOI: 10.1016/j.jhep.2007.02.004
Altmetrics provided by Altmetric
