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Lookup NU author(s): Professor Chris Day
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Nonsteroidal anti-inflammatory drugs are among the most common drugs associated with drug-induced liver injury, with an estimated incidence of between 3 and 23 per 100 000 patient years. Nimesulide, sulindac, and diclofenac seem to be associated with the highest risk and the only risk factor consistently identified is the concomitant use of other hepatotoxic drugs. Diclofenac-induced liver injury is a paradigm for drug-related hepatotoxicity. Recent studies suggest that genetic factors favoring the formation and accumulation of the reactive acylglucuronide metabolite of diclofenac and an enhanced immune response to the metabolite-protein adducts are associated with increased susceptibility to hepatotoxicity. © 2007 Elsevier Inc. All rights reserved.
Author(s): Aithal GP, Day CP
Publication type: Review
Publication status: Published
Journal: Clinics in Liver Disease
Year: 2007
Volume: 11
Issue: 3
Pages: 563-575
ISSN (print): 1089-3261
ISSN (electronic): 1557-8224
URL: http://dx.doi.org/10.1016/j.cld.2007.06.004
DOI: 10.1016/j.cld.2007.06.004
PubMed id: 17723920