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Nonsteroidal Anti-Inflammatory Drug-Induced Hepatotoxicity

Lookup NU author(s): Professor Chris Day

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Abstract

Nonsteroidal anti-inflammatory drugs are among the most common drugs associated with drug-induced liver injury, with an estimated incidence of between 3 and 23 per 100 000 patient years. Nimesulide, sulindac, and diclofenac seem to be associated with the highest risk and the only risk factor consistently identified is the concomitant use of other hepatotoxic drugs. Diclofenac-induced liver injury is a paradigm for drug-related hepatotoxicity. Recent studies suggest that genetic factors favoring the formation and accumulation of the reactive acylglucuronide metabolite of diclofenac and an enhanced immune response to the metabolite-protein adducts are associated with increased susceptibility to hepatotoxicity. © 2007 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Aithal GP, Day CP

Publication type: Review

Publication status: Published

Journal: Clinics in Liver Disease

Year: 2007

Volume: 11

Issue: 3

Pages: 563-575

ISSN (print): 1089-3261

ISSN (electronic): 1557-8224

URL: http://dx.doi.org/10.1016/j.cld.2007.06.004

DOI: 10.1016/j.cld.2007.06.004

PubMed id: 17723920

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