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Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis

Lookup NU author(s): Dr Ahmed Elsharkawy, Professor Derek Mann


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Nuclear factor-κB (NF-κB) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF-κB in the diseased liver. In vivo studies using rodent models of liver disease and cell-targeted perturbation of NF-κB activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma - a process we have termed the "inflammation- fibrosis-cancer axis". This review summarizes the current state of knowledge and provides insight into the vast complexity of the hepatic NF-κB signaling system, which should provide a rich source of new therapeutic targets. Copyright © 2007 by the American Association for the Study of Liver Diseases.

Publication metadata

Author(s): Elsharkawy AM, Mann DA

Publication type: Review

Publication status: Published

Journal: Hepatology

Year: 2007

Volume: 46

Issue: 2

Pages: 590-597

ISSN (print): 0270-9139

ISSN (electronic): 1527-3350


DOI: 10.1002/hep.21802

PubMed id: 17661407