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Interleukin-17 Expression in the Human Placenta

Lookup NU author(s): Dr Roger Searle


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Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA and protein in human placental tissues was investigated. IL-17 mRNA was expressed by purified cytokeratin-positive term placental trophoblast cells, HLA-G+ extravillous trophoblast cells and placental macrophages (Hofbauer cells). IL-17 localized in both cyto- and syncytiotrophoblasts of normal term pregnancy, spontaneous miscarriage and in molar pregnancy. In spontaneous miscarriage and molar pregnancy extravillous trophoblast cells were consistently immunoreactive for IL-17. IL-17 expression in human placenta may play a key role in angiogenesis and/or immunoregulation in the establishment of pregnancy. © 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Pongcharoen S, Somran J, Sritippayawan S, Niumsup P, Chanchan P, Butkhamchot P, Tatiwat P, Kunngurn S, Searle RF

Publication type: Article

Publication status: Published

Journal: Placenta

Year: 2007

Volume: 28

Issue: 1

Pages: 59-63

Print publication date: 01/01/2007

ISSN (print): 0143-4004

ISSN (electronic): 1532-3102

Publisher: Elsevier Ltd


DOI: 10.1016/j.placenta.2006.01.016

PubMed id: 16549200


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