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Extracellular control of TGFβ signalling in vascular development and disease

Lookup NU author(s): Emerita Professor Helen ArthurORCiD

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Abstract

The intracellular mechanism of transforming growth factor-β (TGFβ) signalling via kinase receptors and SMAD effectors is firmly established, but recent studies of human cardiovascular syndromes such as Marfan syndrome and pre-eclampsia have refocused attention on the importance of regulating the availability of active extracellular TGFβ. It seems that elastic extracellular matrix (ECM) components have a crucial role in controlling TGFβ signalling, while soluble and membrane bound forms of TGFβ co-receptors add further layers of regulation. Together, these extracellular interactions determine the final bioavailability of TGFβ to vascular cells, and dysregulation is associated with an increasing number of vascular pathologies. © 2007 Nature Publishing Group.

Publication metadata

Author(s): Ten Dijke P, Arthur HM

Publication type: Review

Publication status: Published

Journal: Nature Reviews Molecular Cell Biology

Year: 2007

Volume: 8

Issue: 11

Pages: 857-869

Print publication date: 01/11/2007

ISSN (print): 1471-0072

ISSN (electronic): 1471-0080

URL: http://dx.doi.org/10.1038/nrm2262

DOI: 10.1038/nrm2262

PubMed id: 17895899

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