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Lookup NU author(s): Professor Helen ArthurORCiD
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The intracellular mechanism of transforming growth factor-β (TGFβ) signalling via kinase receptors and SMAD effectors is firmly established, but recent studies of human cardiovascular syndromes such as Marfan syndrome and pre-eclampsia have refocused attention on the importance of regulating the availability of active extracellular TGFβ. It seems that elastic extracellular matrix (ECM) components have a crucial role in controlling TGFβ signalling, while soluble and membrane bound forms of TGFβ co-receptors add further layers of regulation. Together, these extracellular interactions determine the final bioavailability of TGFβ to vascular cells, and dysregulation is associated with an increasing number of vascular pathologies. © 2007 Nature Publishing Group.
Author(s): Ten Dijke P, Arthur HM
Publication type: Review
Publication status: Published
Journal: Nature Reviews Molecular Cell Biology
Print publication date: 01/11/2007
ISSN (print): 1471-0072
ISSN (electronic): 1471-0080
PubMed id: 17895899