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Lookup NU author(s): Professor Chris Day
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Severe alcoholic steatohepatitis (ASH) is the major complication of advanced alcoholic liver disease (ALD) and has a high mortality even when treated with corticosteroids. Despite the importance of reactive oxygen species in the pathophysiology of ALD and ASH, antioxidants provide no benefit in the treatment of patients with ASH. Proinflammatory cytokines are important in the pathophysiology of ALD and might mediate most of the inflammatory aspects of these disorders. New treatment modalities in ASH might involve antagonism of proinflammatory cytokines such as tumor necrosis factor (TNF) by specific antibodies or other TNF-interfering treatment strategies. Propylthiouracil and S-adenosyl methionine may be beneficial to patients with alcoholic cirrhosis, but both require further randomized, controlled trials before their use can be recommended. Liver transplantation is an effective therapy for patients with advanced alcoholic cirrhosis who have not recovered after a period of abstinence.
Author(s): Day CP
Publication type: Article
Publication status: Published
Journal: Liver Transplantation
Year: 2007
Volume: 13
Issue: s2
Pages: 69-75
ISSN (print): 1527-6465
ISSN (electronic): 1527-6473
Publisher: John Wiley & Sons, Inc.
URL: http://dx.doi.org/10.1002/lt.21336
DOI: 10.1002/lt.21336
PubMed id: 17969070
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