Browse by author
Lookup NU author(s): Professor Chris Day
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background/Aims: To compare carotid intima-media thickness (IMT) - an index of early atherosclerosis - among patients with non-alcoholic steatohepatitis (NASH), patients with chronic hepatitis B (HBV) or C (HCV) and control subjects. Methods: We studied 60 consecutive patients with biopsy-proven NASH, 60 patients with HCV, 35 patients with HBV, and 60 healthy controls who were comparable for age and sex. Common carotid IMT was measured with ultrasonography in all participants by a single operator blinded to subjects' characteristics. Results: Carotid IMT measurements were markedly different among the groups; the lowest values were in controls, intermediate in patients with HBV or HCV, and highest in those with NASH (0.84 ± 0.1 vs. 0.97 ± 0.1 vs. 1.09 ± 0.2 vs. 1.23 ± 0.2 mm, respectively; p < 0.001). The marked differences in carotid IMT that were observed among the groups were little affected by adjustment for age, sex, body mass index, smoking, LDL cholesterol, insulin resistance (by homeostasis model assessment) and components of the Adult Treatment Panel III-defined metabolic syndrome. Concordantly, in logistic regression analysis, NASH, HBV and HCV predicted carotid IMT independent of potential confounders. Conclusions: These data suggest that NASH, HCV and HBV are strongly associated with early atherosclerosis independent of classical risk factors, insulin resistance and metabolic syndrome components. © 2007 European Association for the Study of the Liver.
Author(s): Targher G, Bertolini L, Padovani R, Rodella S, Arcaro G, Day C
Publication type: Article
Publication status: Published
Journal: Journal of Hepatology
Year: 2007
Volume: 46
Issue: 6
Pages: 1126-1132
ISSN (print): 0168-8278
ISSN (electronic): 1600-0641
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/j.jhep.2007.01.021
DOI: 10.1016/j.jhep.2007.01.021
PubMed id: 17335930
Altmetrics provided by Altmetric
