Lookup NU author(s): Kathleen Allinson,
Professor Helen Arthur
Endoglin is an auxiliary receptor for TGFβ signalling. Heterozygous germline Endoglin mutations have been identified in patients with the vascular abnormality, Hereditary Haemorrhagic Telangiectasia. Endoglin is upregulated in endothelial cells during angiogenesis and loss of Endoglin in the mouse results in embryonic lethality at mid-gestation. This phenotype points to an important role of Endoglin in new blood vessel formation but precludes analysis at later stages in development and in postnatal life. To bypass this limitation and allow further investigations of the function of Endoglin we have generated a floxed Endoglin allele in which loxP sites flank exons 5 and 6. Mice homozygous for this allele are normal and in the presence of appropriate Cre lines will allow time and cell specific Endoglin deletion for in vivo analysis of function in cardiovascular development and disease. © 2007 Wiley-Liss, Inc.
Author(s): Allinson KR, Carvalho RLC, Van Den Brink S, Mummery CL, Arthur HM
Publication type: Article
Publication status: Published
Journal: Genesis: The Journal of Genetics and Development
Print publication date: 01/06/2007
ISSN (print): 1526-954X
ISSN (electronic): 1526-968X
Publisher: John Wiley & Sons, Inc.
PubMed id: 17506087
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