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TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts

Lookup NU author(s): Dr Gabriele Saretzki, Dr Glyn Nelson, Dr Sharon Olijslagers, Professor Thomas von Zglinicki

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Abstract

Repair of single strand breaks in telomeric DNA is less efficient than in other genomic regions. This leads to an increased vulnerability of telomeric DNA towards damage induced by reactive oxygen species (ROS) and to accelerated telomere shortening under oxidative stress. The causes for the diminished repair efficacy in telomeres are unknown. We show here that overexpression of the telomere-binding protein TRF2 further reduces telomeric, but not genomic, single strand break repair. This suggests the possibility of strand break repair in telomeres being sterically hindered by the three-dimensional structure of the telomere DNA-protein complex and explains the effect of TRF2 on telomere shortening rates in telomerase-negative cells. © 2007 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Richter T, Saretzki G, Nelson G, Melcher M, Olijslagers S, von Zglinicki T

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2007

Volume: 128

Issue: 4

Pages: 340-345

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.mad.2007.02.003

DOI: 10.1016/j.mad.2007.02.003

PubMed id: 17395247


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