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Lookup NU author(s): Emeritus Professor Andrew Rugg-Gunn
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Objectives: This study aimed to confirm a previously obtained value for the fractional urinary fluoride excretion (FUFE) over a 24-hour period in adults and to assess whether there are significant differences between FUFE measured during the diurnal (7 a.m. and 6 p.m.) and the subsequent nocturnal (6 p.m. until 7 a.m. of the following day) periods. Methods: Urine was collected over 24 h from 60 healthy female volunteers residing in Santiago, Chile. The individuals' fluoride intakes over the diurnal and nocturnal periods were calculated from their corresponding F ingestion, measured by dietary analysis. Separate urine collections during both periods were obtained from each volunteer. The fluoride concentrations were measured with a fluoride-ion- selective electrode either directly (urine, water and beverages) or after sample treatment with the microdiffusion technique (food). Results: The average 24-hour FUFE value was 0.69, with a 95% CI of 0.65-0.72, while the average FUFE for the diurnal period was 0.46 (95% CI: 0.42-0.50), and the corresponding result for the nocturnal period showed a significantly higher (paired t test, p < 0.0001) amount of 1.09 (95% CI: 0.97-1.22). Conclusions: A recently published result for the daily FUFE value (0.71) in adults was confirmed. The diurnal average FUFE value is significantly lower than the average nocturnal one. Accepting that approximately 10% of the fluoride intake is not absorbed, the daily fluoride retention can be preliminarily estimated as 20% of the ingested fluoride. Copyright © 2008 S. Karger AG.
Author(s): Villa A, Anabalon M, Cabezas L, Rugg-Gunn A
Publication type: Article
Publication status: Published
Journal: Caries Research
ISSN (print): 0008-6568
ISSN (electronic): 1421-976X
Publisher: S. Karger AG
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