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The function of serotonin within the liver

Lookup NU author(s): Professor Derek Mann


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Serotonin or 5-hydroxytryptamine (5-HT) is known to regulate several key aspects of liver biology and these functions include hepatic blood flow, innervation and wound healing. Given the importance of these functions it is surprising that relatively little time has been dedicated to studying the precise function and mechanisms of serotonin within the liver. Here we describe what is known about serotonin and the liver and those receptor types that mediate the observed effects with an aim to stimulating new interest in the field of serotonin and liver biology. © 2008 European Association for the Study of the Liver.

Publication metadata

Author(s): Ruddell RG, Mann DA, Ramm GA

Publication type: Review

Publication status: Published

Journal: Journal of Hepatology

Year: 2008

Volume: 48

Issue: 4

Pages: 666-675

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641


DOI: 10.1016/j.jhep.2008.01.006

PubMed id: 18280000