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Lookup NU author(s): Professor Mark Cunningham,
Professor Miles Whittington
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The seminal in vivo work of Mircea Steriade and his colleagues has, as is always the case with the most insightful and creative scientists, raised many serious questions: questions, for example, of the detailed cellular and molecular mechanisms of the phenomena they discovered. In our tribute to this great investigator, we shall present some examples, based on our in vitro and modeling work, that shed light on some of his remarkable breakthroughs: the slow oscillation of sleep (<1 Hz); the several types of fast oscillations that are superimposed on the intracellular depolarizing, or active, phases of the slow oscillation; and the transition from slow oscillation to seizure via a period of very fast (>70 Hz) oscillations. © 2008 Cambridge University Press.
Author(s): Traub RD, Cunningham MO, Whittington MA
Publication type: Review
Publication status: Published
Journal: Thalamus & Related Systems
ISSN (print): 1472-9288