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Fast oscillations in activated neocortical brain slices: An in vitro continuation of the pioneering in vivo studies of Mircea Steriade and colleagues

Lookup NU author(s): Professor Mark Cunningham, Professor Miles Whittington


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The seminal in vivo work of Mircea Steriade and his colleagues has, as is always the case with the most insightful and creative scientists, raised many serious questions: questions, for example, of the detailed cellular and molecular mechanisms of the phenomena they discovered. In our tribute to this great investigator, we shall present some examples, based on our in vitro and modeling work, that shed light on some of his remarkable breakthroughs: the slow oscillation of sleep (<1 Hz); the several types of fast oscillations that are superimposed on the intracellular depolarizing, or active, phases of the slow oscillation; and the transition from slow oscillation to seizure via a period of very fast (>70 Hz) oscillations. © 2008 Cambridge University Press.

Publication metadata

Author(s): Traub RD, Cunningham MO, Whittington MA

Publication type: Review

Publication status: Published

Journal: Thalamus & Related Systems

Year: 2008

Volume: 4

Issue: 1

Pages: 79-86

ISSN (print): 1472-9288

ISSN (electronic):


DOI: 10.1017/S1472928808000344