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Complexity of COX-2 gene regulation

Lookup NU author(s): Kelly Harper, Professor Alison Tyson-Capper

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Abstract

Overexpression of the enzyme COX-2 (cyclo-oxygenase-2) is associated with various pathophysiological conditions, including inflammatory diseases and different cancers. Increased synthesis of COX-2 in fetal membranes and the myometrium is also linked with the onset of term and preterm labour. COX-2 gene regulation is controlled at various levels including gene transcription and post-transcriptional events. The present article focuses on the complexity of COX-2 gene regulation and reviews current concepts that highlight: (i) transcription of COX-2 is induced rapidly and transiently in response to a plethora of stimuli; (ii) COX-2 mRNA stability and translational efficiency is governed by multiple regulatory elements within the 3′-untranslated region; (iii) specific microRNAs and RNA-binding proteins influence COX-2 mRNA stability; and (iv) regulation of COX-2 involves alternative polyadenylation. ©The Authors.

Publication metadata

Author(s): Harper KA, Tyson-Capper AJ

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2008

Volume: 36

Issue: 3

Pages: 543-545

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0360543

DOI: 10.1042/BST0360543

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