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The Genetics of Cancer Survivorship

Lookup NU author(s): Professor James Allan


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Constitutional (hereditary) genetic variation and somatic genetic alterations acquired during transformation to the neoplastic phenotype are both critical determinants of cancer outcome, and can ultimately have a significant effect on cancer survivorship. This article discusses the role of constitutional and somatic genetics in determining outcome and survivorship following a diagnosis of cancer using illustrative examples primarily from the hematologic malignancies. © 2008 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Allan JM

Publication type: Review

Publication status: Published

Journal: Hematology/Oncology Clinics of North America

Year: 2008

Volume: 22

Issue: 2

Pages: 257-269

ISSN (print): 0889-8588

ISSN (electronic): 1558-1977


DOI: 10.1016/j.hoc.2008.01.001

PubMed id: 18395149