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Lookup NU author(s): Professor James Allan
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Constitutional (hereditary) genetic variation and somatic genetic alterations acquired during transformation to the neoplastic phenotype are both critical determinants of cancer outcome, and can ultimately have a significant effect on cancer survivorship. This article discusses the role of constitutional and somatic genetics in determining outcome and survivorship following a diagnosis of cancer using illustrative examples primarily from the hematologic malignancies. © 2008 Elsevier Inc. All rights reserved.
Author(s): Allan JM
Publication type: Review
Publication status: Published
Journal: Hematology/Oncology Clinics of North America
ISSN (print): 0889-8588
ISSN (electronic): 1558-1977
PubMed id: 18395149