Toggle Main Menu Toggle Search

Open Access padlockePrints

Epigenetic regulation of hepatic stellate cell activation

Lookup NU author(s): Professor Derek Mann, Professor Jelena Mann


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Activation of hepatic stellate cells (HSC) to a myofibroblast-like phenotype is the pivotal event in liver fibrosis. In uninjured liver, HSC are quiescent and non-dividing, but upon liver injury these cells undergo a dramatic change in phenotype which generates activated myofibroblast-like HSC. The change in phenotype is underpinned by a global change in gene expression with hundreds of genes being up- or downregulated. Molecular events that orchestrate changes in gene expression take place at the level of chromatin packaging which is altered through three main processes: histone modifications, DNA methylation, and silencing by non-coding RNAs. The present review focuses on the epigenetic regulation of HSC activation. © 2007 The Authors.

Publication metadata

Author(s): Mann DA, Mann J

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Journal of Gastroenterology and Hepatology: 2nd International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis

Year of Conference: 2008

Pages: S108-S111

ISSN: 0815-9319

Publisher: Wiley-Blackwell Publishing Asia


DOI: 10.1111/j.1440-1746.2007.05295.x

Library holdings: Search Newcastle University Library for this item

ISBN: 14401746