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Lookup NU author(s): Professor Richard Boys,
Professor Darren Wilkinson,
Emeritus Professor Thomas Kirkwood
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The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient. © 2007 Springer Science+Business Media, LLC.
Author(s): Boys RJ, Wilkinson DJ, Kirkwood TBL
Publication type: Article
Publication status: Published
Journal: Statistics and Computing
ISSN (print): 0960-3174
ISSN (electronic): 1573-1375
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