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A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

Lookup NU author(s): Dr Nicola Sunter, Emeritus Professor Andy Hall, Dr Tryfonia Mainou-Fowler, Professor Graham Jackson, Professor James Allan

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Abstract

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 × 10 -10), 2q37.1 (rs13397985, SP140; P = 5.40 × 10-10), 6p25.3 (rs872071, IRF4; P = 1.91 × 10-20), 11q24.1 (rs735665; P = 3.78 × 10-12), 15q23 (rs7176508; P = 4.54 × 10 -12) and 19q13.32 (rs11083846, PRKD2; P = 3.96 × 10 -9). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.


Publication metadata

Author(s): Di Bernardo M, Crowther-Swanepoel D, Broderick P, Webb E, Sellick G, Wild R, Sullivan K, Vijayakrishnan J, Wang Y, Pittman A, Sunter N, Hall AG, Dyer M, Matutes E, Dearden C, Mainou-Fowler T, Jackson GH, Summerfield G, Harris R, Pettitt A, Hillmen P, Allsup D, Bailey J, Pratt G, Pepper C, Fegan C, Allan JM, Catovsky D, Houlston R

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2008

Volume: 40

Issue: 10

Pages: 1204-1210

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ng.219

DOI: 10.1038/ng.219


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Funding

Funder referenceFunder name
CLL Global Research Foundation, Cancer Research UK
C1298/A8362Bobby Moore Fund
CPRB LSHC-CT-2004-503465European Union
LRF05001 and 06002Leukaemia Research Fund (LRF)

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