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Lookup NU author(s): Garrett Durkan, Dr Ian Brotherick, Kilian Mellon
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Objective To evaluate soluble E-cadherin (sE-cadherin) as a potential tumour marker in patients with transitional cell carcinoma (TCC) of the bladder (previously shown to correlate with tumour grade, number of Ta/T1 tumours at presentation and a positive 3-month check cystoscopy) by assessing its serum concentration in relation to transurethral resection of bladder tumour (TURBT). Patients and methods Samples of venous blood were obtained from 25 patients with bladder cancer: ii) before cystoscopy/TURBT: iii intraoperatively, during tumour resection: and (iii! on the first day after surgery. Levels of sE-cadherin were measured using an enzyme-linked immunosorbent assay. Results Sixty-three serum samples from patients with TCC of the bladder were available for analysis (23 before, 21 during and 19 after surgery). Patients with G2/3 tumours had significantly higher median preoperative levels of sE-cadherin (16.37 and 13.03 mu g/mL, respectively) than those with G1 tumours (9.493 mu g/mL; P= 0.0164). There was no correlation between tumour stage and preoperative sE-cadherin concentration. The median concentrations of sE-cadherin were not significantly different before, during and after TURBT. Conclusions This study confirmed the previous finding that higher levels of serum sE-cadherin correlate with increasing tumour grade but not with clinicopathological stage. Serum sE-cadherin levels are not significantly altered by TURBT in the immediate perioperative period.
Author(s): Durkan GC, Brotherick I, Mellon JK
Publication type: Article
Publication status: Published
Journal: BJU International
Year: 1999
Volume: 83
Issue: 4
Pages: 424-428
ISSN (print): 1464-4096
ISSN (electronic): 1464-410X
Publisher: Wiley-Blackwell Publishing Ltd.
URL: http://dx.doi.org/10.1046/j.1464-410x.1999.00972.x
DOI: 10.1046/j.1464-410x.1999.00972.x
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