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Genetic epidemiology of environmental toxicity and cancer susceptibility: Human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues

Lookup NU author(s): Professor Ann DalyORCiD


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Pharmacogenetics is the study of idiosyncratic drug responses that have an hereditary basis and usually reflect differences in drug-metabolizing enzymes (DMEs) and the receptors that control DME levels. The purpose of this review is to provide a brief overview of recent findings concerning more than a dozen clinically important polymorphisms and to emphasize the need to standardize the nomenclature of these alleles in each polymorphism, as quickly as possible. This nomenclature system should be consistent with the Human Gene Nomenclature Guidelines.

Publication metadata

Author(s): Daly AK; Nebert DW; Ingelman-Sundberg M

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Satellite Symposium on Microsomes, Drug Oxidation, and Clinical Pharmacology

Year of Conference: 1999

Pages: 467-487

ISSN: 0360-2532

Publisher: Informa Healthcare


DOI: 10.1081/DMR-100101931

Library holdings: Search Newcastle University Library for this item

Series Title: Drug Metabolism Reviews

ISBN: 10979883