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Up-regulation of natural killer cell cytotoxicity by interleukin-2: The effect of sex and parity

Lookup NU author(s): Dr Roger Searle, Dr Judith Bulmer

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Abstract

PROBLEM: Peripheral blood lymphocytes (PBLs) from some, but not all, female donors showed increased cytotoxicity in response to interleukin (IL)-2. METHOD OF STUDY: The effect of IL-2 on natural killer (NK) cell cytotoxicity was compared in nulliparous females, parous females, and males. Peripheral blood lymphocytes were preincubated for 20 or 72 hr with 5 or 100 U/ml IL-2 and cytotoxicity against K562 targets was then examined. RESULTS: In the parous females, only the 72-hr preincubation with 100 U/ml IL-2 significantly increased NK cell cytotoxicity, whereas nulliparous females also showed significantly increased cytotoxicity after a 20-hr preincubation with 100 U/ml IL-2. Neither female subject group had increased activity after preincubation for 20 or 72 hr with 5 U/ml IL-2. However, male peripheral blood lymphocytes also showed a significant increase in NK cell cytotoxicity when preincubated for 72 hr with 5 U/ml IL-2. CONCLUSIONS: The effect of IL-2 on NK cell cytotoxic activity may be related to sex and the state of parity.

Publication metadata

Author(s): Bulmer JN; Searle RF; Brett R

Publication type: Article

Publication status: Published

Journal: American Journal of Reproductive Immunology

Year: 1999

Volume: 41

Issue: 5

Pages: 356-359

Print publication date: 06/09/2011

ISSN (print): 1046-7408

ISSN (electronic): 1600-0897

Publisher: Wiley-Blackwell Publishing, Inc.

URL: http://dx.doi.org/10.1111/j.1600-0897.1999.tb00450.x

DOI: 10.1111/j.1600-0897.1999.tb00450.x

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