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Lookup NU author(s): Dr Sudagar Gurcha, Professor Del Besra
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The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new. safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(alpha -D-arabinofuranosyl)-alpha -D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for Al. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
Author(s): Pathak AK, Pathak V, Maddry JA, Suling WJ, Gurcha SS, Besra GS, Reynolds RC
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry
Year: 2001
Volume: 9
Issue: 12
Pages: 3145-3151
ISSN (print):
ISSN (electronic): 1464-3391
Publisher: Pergamon
URL: http://dx.doi.org/10.1016/S0968-0896(01)00180-8
DOI: 10.1016/S0968-0896(01)00180-8
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