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Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?

Lookup NU author(s): Emerita Professor Loranne Agius

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Abstract

Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there are multiple subcellular pools of glucose 6-phosphate. It is proposed that this data can be interpreted in terms of channelling of metabolic intermediates through multiple pathways of glucose metabolism with leakage of glucose 6-phosphate from the channels into a single free pool. It is also proposed that measurement of total tissue content of glucose 6-phosphate approximates the free pool.

Publication metadata

Author(s): Agius L, Centelles J, Cascante M

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: Meeting on High-Throughput Screening - The Way Ahead

Year of Conference: 2002

Pages: 38-43

ISSN: 0300-5127

Publisher: Portland Press Ltd.

Library holdings: Search Newcastle University Library for this item

ISBN: 14708752

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