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PARP-1: a regulator of genomic stability linked with mammalian longevity

Lookup NU author(s): Professor Alexander Burkle

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Abstract

Guardian of the genome: Covalent modification of proteins with poly(ADP-ribose) (see picture), catalysed by the enzyme poly(ADP-ribose) polymerase-1 (PARP-1), is a rapid cellular response to DNA damage and contributes to genome stabilization in cells under genotoxic stress. Interestingly, the capacity of lymphocytes to produce poly(ADP-ribose) is correlated with the life span of mammalian species, thus suggesting a functional role for PARP-1 in longevity.

Publication metadata

Author(s): Burkle A

Publication type: Review

Publication status: Published

Journal: ChemBioChem

Year: 2001

Volume: 2

Issue: 10

Pages: 725-728

ISSN (print): 1439-4227

ISSN (electronic): 1439-7633

URL: http://dx.doi.org/10.1002/1439-7633(20011001)2:10<725::AID-CBIC725>3.0.CO;2-3

DOI: 10.1002/1439-7633(20011001)2:10<725::AID-CBIC725>3.0.CO;2-3

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