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Lookup NU author(s): Professor Alexander Burkle
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Guardian of the genome: Covalent modification of proteins with poly(ADP-ribose) (see picture), catalysed by the enzyme poly(ADP-ribose) polymerase-1 (PARP-1), is a rapid cellular response to DNA damage and contributes to genome stabilization in cells under genotoxic stress. Interestingly, the capacity of lymphocytes to produce poly(ADP-ribose) is correlated with the life span of mammalian species, thus suggesting a functional role for PARP-1 in longevity.
Author(s): Burkle A
Publication type: Review
Publication status: Published
ISSN (print): 1439-4227
ISSN (electronic): 1439-7633