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Genetics of type 2 diabetes and insulin resistance: knowledge from human studies

Lookup NU author(s): Dr Elizabeth McIntyre, Professor Mark Walker


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Both type 2 diabetes mellitus (T2DM) and insulin resistance are complex traits in which multiple gene effects and metabolic and environmental factors combine to contribute to the overall pathogenesis of these conditions. This complexity has complicated the search for susceptibility genes and has led to different but complementary approaches being used for the detection of gene effects. These include the study of monogenic cases of insulin resistance and T2DM, association studies of candidate genes and genome-wide scans. The peroxisome proliferator-activated receptor gamma (PPARgamma) and calpain-10 (CAPN10) genes have recently been identified as T2DM susceptibility genes, and the lessons learnt from these studies are helping to shape future strategies to search for additional susceptibility genes in T2DM and insulin resistance.

Publication metadata

Author(s): Walker M; McIntyre EA

Publication type: Review

Publication status: Published

Journal: Clinical Endocrinology

Year: 2002

Volume: 57

Issue: 3

Pages: 303-311

ISSN (print): 0300-0664

ISSN (electronic): 1365-2265


DOI: 10.1046/j.1365-2265.2002.01610.x