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Lookup NU author(s): Professor John Hesketh
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The pathogenic mechanisms responsible for alcohol-induced muscle disease are unknown, although it is possible that increased proto-oncogene expression may be the causative process. Therefore, we investigated the responses of skeletal muscle c-myc protein and mRNA to a standard acute ethanol dosage regimen (75 mmol/kg/body weight [BW]) for 2.5 to 24 hours. Comparative studies were made on the heart. Acute ethanol administration in vivo led to an increase in c-myc proto-oncogene mRNA in rat skeletal and cardiac muscle. The changes in c-myc mRNA were mirrored by increases in the c-myc protein as demonstrated by immunohistochernistry. The changes in the c-myc protein were localized to the myonuclei, with no corresponding changes seen in the interstitial cell nuclei. This is the first report of altered proto-oncogene expression in muscle in response to ethanol. Increased c-myc mRNA and protein may reflect adaptive changes, a stress response, or another uncharacterized cellular adaptation. Copyright 2002, Elsevier Science (USA). All rights reserved.
Author(s): Hesketh JE; Paice AG; Towner P; Hirako M; Peters TJ; Preedy VR
Publication type: Article
Publication status: Published
Journal: Metabolism
Year: 2002
Volume: 51
Issue: 10
Pages: 1285-1290
ISSN (print): 0026-0495
ISSN (electronic): 1532-8600
Publisher: W.B. Saunders Co.
URL: http://dx.doi.org/10.1053/meta.2002.34709
DOI: 10.1053/meta.2002.34709
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