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Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry

Lookup NU author(s): Dr Emma Burton, Dr Sean Paling, Dr Robert Barber, Professor David Williams, Dr Clive Ballard, Professor Ian McKeith, Professor John O'Brien


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Previous cross-sectional MRI studies based on region-of-interest analyses have shown that increased cerebral atrophy is a feature of both Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Relative preservation of the hippocampus and temporal lobe structures in DLB compared to AD has been reported in region-of-interest-based studies. Recently, image processing techniques such as voxel-based morphometry (VBM) have been developed to provide an unbiased, visually informative, and comprehensive means of studying patterns of cerebral atrophy. We report the first study to use the voxel-based approach to assess patterns of cerebral atrophy in DLB compared to control subjects and AD. Regional gray matter volume loss was observed bilaterally in the temporal and frontal lobes and insular cortex of patients with DLB compared to control subjects. Comparison of dementia groups showed preservation of the medial temporal lobe, hippocampus, and amygdala in DLB relative to AD. Significant gray matter loss was also observed in the thalamus of AD patients compared to DLB. (C) 2002 Elsevier Science (USA).

Publication metadata

Author(s): McKeith IG; O'Brien JT; Burton EJ; Barber R; Ballard CG; Paling SM; Karas G; Williams ED; Scheltens P; Barkhof F

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2002

Volume: 17

Issue: 2

Pages: 618-630

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Academic Press


DOI: 10.1006/nimg.2002.1197


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