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Expression of CYP2S1 in human hepatic stellate cells

Lookup NU author(s): Dr Carlyn Marek, Dr Karen Wallace, Professor Matthew Wright


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Activated stellate cells are myofibroblast-like cells associated with the generation of fibrotic searing in chronically damaged liver. Gene chip analysis was performed on cultured fibrotic stellate cells. Of the 51 human CYP genes known, 13 CYP and 5 CYP reduction-related genes were detected with 4 CYPs (CYP1A1, CYP2E1, CY2S1 and CYP4F3) consistently present in stellate cells isolated from three individuals. Quantitative RT-PCR indicated that CYP2S1 was a major expressed CYP mRNA transcript. The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1. (c) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Publication metadata

Author(s): Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2007

Volume: 581

Issue: 4

Pages: 781-786

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier


DOI: 10.1016/j.febslet.2007.01.056


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