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Lookup NU author(s): Dr Carlyn Marek,
Dr Karen Wallace,
Professor Matthew Wright
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Activated stellate cells are myofibroblast-like cells associated with the generation of fibrotic searing in chronically damaged liver. Gene chip analysis was performed on cultured fibrotic stellate cells. Of the 51 human CYP genes known, 13 CYP and 5 CYP reduction-related genes were detected with 4 CYPs (CYP1A1, CYP2E1, CY2S1 and CYP4F3) consistently present in stellate cells isolated from three individuals. Quantitative RT-PCR indicated that CYP2S1 was a major expressed CYP mRNA transcript. The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1. (c) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Author(s): Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC
Publication type: Article
Publication status: Published
Journal: FEBS Letters
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
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