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Posttransplantation cytomegalovirus-induced recurrence of atypical hemolytic uremic syndrome associated with a factor H mutation: Successful treatment with intensive plasma exchanges and ganciclovir

Lookup NU author(s): Professor Tim Goodship, Dr Lisa Turnbull


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. Atypical hemolytic uremic syndrome (HUS) can recur after renal transplantation and often leads to graft loss. In some series of familial HUS, the risk of early graft loss due to recurrence of HUS approaches 100% despite any therapy. This led some authors to claim that kidney transplantation is contraindicated In those patients. The authors describe an 8-year-old girl with end-stage renal failure owing to familial atypical HUS with a factor H mutation who underwent successful transplantation using continuous prophylactic plasma exchange (PE). Twenty-four months after transplantation, plasma creatinine level Is 1.2 mg/dL (106 mumol/L) despite 2 recurrences of HUS contemporaneous to 2 cytomegalovirus Infections, which resolved with PE Intensification and ganciclovir. This strongly suggests that cytomegalovirus Infection may trigger posttransplant recurrent HUS. The feasibility of kidney transplantation in case of atypical HUS related to factor H mutation using continuous prophylactic PE intensified during relapses should be confirmed In prospective studies. (C) 2004 by the National Kidney Foundation, Inc.

Publication metadata

Author(s): Olie KH, Goodship THJ, Verlaak R, Florquin S, Groothoff JW, Strain L, Weening JJ, Davin JC

Publication type: Article

Publication status: Published

Journal: American Journal of Kidney Diseases

Year: 2005

Volume: 45

Issue: 1

Pages: E12-E15

ISSN (print): 0272-6386

ISSN (electronic): 1523-6838

Publisher: WB Saunders Co.


DOI: 10.1053/j.ajkd.2004.09.012


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