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OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age

Lookup NU author(s): Professor Deborah Tweddle, Mike Cole, Professor Andrew Pearson


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Background. This paper reports the toxicity of OPEC/OJEC chemotherapy in stage 4 neuroblastoma patients over 1 year of age. Procedure. Ninety-five patients with stage 4 neuroblastoma received alternating courses of OPEC/ OJEC-vincristine 1.5 mg/m(2) (O), cisplatin 80 mg/m(2) (P), etoposide 200 mg/m(2) (E), cyclophosphamide 600 mg/m(2) (C), and carboplatin 500 mg/m(2) U), every 21 days if there was haematological recovery. Results. Seventy out of ninety-five (74%) patients completed seven or more courses and were evaluable for toxicity. Of these 70 patients, 33% had more than three episodes of fever and sepsis, 35% required more than five blood or platelet transfusions, 36% had grade 2 or more gastrointestinal toxicity and 9% had neurotoxicity. There was a median reduction in GFR of 32 ml/min/1.73 m(2) (-46 to 134) and there was one toxic death. Conclusions. OPEC/OJEC is a well-tolerated therapy for stage 4 neuroblastoma over 1 year of age. Med. Pediatr. Oncol. 36:239-242, 2001. (C) 2001 Wiley-Liss, Inc.

Publication metadata

Author(s): Tweddle, D. A., Pinkerton, C. R., Lewis, I. J., Ellershaw, C., Cole, M., Pearson, A. D. J.

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 2001

Volume: 36

Issue: 1

Pages: 239-242

ISSN (print): 0098-1532

ISSN (electronic):


DOI: 10.1002/1096-911X(20010101)36:1<239::AID-MPO1058>3.0.CO;2-G

Notes: Published in special issue of Medical and Pediatric Oncology: Advances in Neuroblastoma Research: 1998 Conference


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