Toggle Main Menu Toggle Search

Open Access padlockePrints

OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age

Lookup NU author(s): Professor Deborah Tweddle, Mike Cole, Professor Andrew Pearson

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Background. This paper reports the toxicity of OPEC/OJEC chemotherapy in stage 4 neuroblastoma patients over 1 year of age. Procedure. Ninety-five patients with stage 4 neuroblastoma received alternating courses of OPEC/ OJEC-vincristine 1.5 mg/m(2) (O), cisplatin 80 mg/m(2) (P), etoposide 200 mg/m(2) (E), cyclophosphamide 600 mg/m(2) (C), and carboplatin 500 mg/m(2) U), every 21 days if there was haematological recovery. Results. Seventy out of ninety-five (74%) patients completed seven or more courses and were evaluable for toxicity. Of these 70 patients, 33% had more than three episodes of fever and sepsis, 35% required more than five blood or platelet transfusions, 36% had grade 2 or more gastrointestinal toxicity and 9% had neurotoxicity. There was a median reduction in GFR of 32 ml/min/1.73 m(2) (-46 to 134) and there was one toxic death. Conclusions. OPEC/OJEC is a well-tolerated therapy for stage 4 neuroblastoma over 1 year of age. Med. Pediatr. Oncol. 36:239-242, 2001. (C) 2001 Wiley-Liss, Inc.


Publication metadata

Author(s): Tweddle, D. A., Pinkerton, C. R., Lewis, I. J., Ellershaw, C., Cole, M., Pearson, A. D. J.

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 2001

Volume: 36

Issue: 1

Pages: 239-242

ISSN (print): 0098-1532

ISSN (electronic):

URL: http://dx.doi.org/10.1002/1096-911X(20010101)36:1<239::AID-MPO1058>3.0.CO;2-G

DOI: 10.1002/1096-911X(20010101)36:1<239::AID-MPO1058>3.0.CO;2-G

Notes: Published in special issue of Medical and Pediatric Oncology: Advances in Neuroblastoma Research: 1998 Conference


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share