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Lookup NU author(s): Professor Andrew Pearson,
Professor Alan Boddy
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Purpose: The pharmacokinetics and metabolism of cyclophosphamide (CPA) when given as a l-h and a 24-h infusion to children were compared. Methods: Thirteen children with a variety of different malignancies received an identical dose of cyclophosphamide as a 1- and 24-h infusion. In each case the concentration of CPA and its principal metabolites were measured by a thin-layer-chromatography-pho to graphic-densitometry technique. Results: Cyclophosphamide clearance was greater during the 24-h infusion, following time-dependent increases in the metabolism of the drug (autoinduction) (median 5.1 vs 3.1 1/h/m(2): P=0.037). Autoinduction was seen in five children (38%), producing a median end of infusion concentration of 49% (range 28-89%) of the maximum and was not accompanied by an increase in the production of the principal inactive metabolites carboxyphosphamide and dechloroethylcyclophosphamide. Conclusions: These results suggest potential benefits of prolonging the infusion of CPA in clinical practice.
Author(s): Yule, SM, Price, L, Cole, M, Pearson, ADJ, Boddy, AV
Publication type: Article
Publication status: Published
Journal: Cancer Chemotherapy and Pharmacology
ISSN (print): 0344-5704
ISSN (electronic): 1432-0843
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