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Cyclophosphamide metabolism in children following a 1-h and a 24-h infusion

Lookup NU author(s): Professor Andrew Pearson, Professor Alan Boddy


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Purpose: The pharmacokinetics and metabolism of cyclophosphamide (CPA) when given as a l-h and a 24-h infusion to children were compared. Methods: Thirteen children with a variety of different malignancies received an identical dose of cyclophosphamide as a 1- and 24-h infusion. In each case the concentration of CPA and its principal metabolites were measured by a thin-layer-chromatography-pho to graphic-densitometry technique. Results: Cyclophosphamide clearance was greater during the 24-h infusion, following time-dependent increases in the metabolism of the drug (autoinduction) (median 5.1 vs 3.1 1/h/m(2): P=0.037). Autoinduction was seen in five children (38%), producing a median end of infusion concentration of 49% (range 28-89%) of the maximum and was not accompanied by an increase in the production of the principal inactive metabolites carboxyphosphamide and dechloroethylcyclophosphamide. Conclusions: These results suggest potential benefits of prolonging the infusion of CPA in clinical practice.

Publication metadata

Author(s): Yule, SM, Price, L, Cole, M, Pearson, ADJ, Boddy, AV

Publication type: Article

Publication status: Published

Journal: Cancer Chemotherapy and Pharmacology

Year: 2001

Volume: 47

Issue: 3

Pages: 222-228

ISSN (print): 0344-5704

ISSN (electronic): 1432-0843

Publisher: Springer


DOI: 10.1007/s002800000220


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