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Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia

Lookup NU author(s): Professor John O'Brien, Dr Sean Paling, Dr Robert Barber, Professor David Williams, Dr Clive Ballard, Professor Ian McKeith, Dr Anil Gholkar OBE


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The authors determined rates of brain atrophy, as assessed by the boundary shift integral on serial MRI, in patients with dementia with Lewy Bodies (DLB, n = 10), AD (n = 9), vascular dementia (VaD, n = 9), and age-matched controls (n = 20). Mean % +/- SD atrophy rates per year were as follows: DLB, 1.4 +/- 1.1; AD, 2.0 +/- 0.9; VaD, 1.9 +/- 1.1; and controls, 0.5 +/- 0.7. Dementia subjects had higher rates than controls (p < 0.001), but there were no significant differences between the three dementia groups. The authors found accelerating atrophy with increasing severity of cognitive impairment, further emphasizing the need for early diagnosis and intervention in dementia.

Publication metadata

Author(s): Gholkar A; McKeith IG; O'Brien JT; Barber R; Ballard C; Paling S; Williams ED; Crum WR; Rossor MN; Fox NC

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2001

Volume: 56

Issue: 10

Pages: 1386-1388

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins