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t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci, Professor Anthony Moorman

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Abstract

The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus-specific probes confirmed the involvement of the IGH@ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)-positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia.


Publication metadata

Author(s): Robinson HM, Taylor KE, Jalali GR, Cheung KL, Harrison CJ, Moorman AV

Publication type: Article

Publication status: Published

Journal: Genes, Chromosomes and Cancer

Year: 2004

Volume: 39

Issue: 1

Pages: 88-92

ISSN (print): 1045-2257

ISSN (electronic): 1098-2264

URL: http://dx.doi.org/10.1002/gcc.10299

DOI: 10.1002/gcc.10299

Notes: Journal Article Research Support, Non-U.S. Gov't United States


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