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NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex

Lookup NU author(s): Dr Steven Middleton, Dr Fiona LeBeauORCiD, Dr Anita Roopun, Professor Miles Whittington, Professor Mark Cunningham

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Abstract

Local circuits in the medial entorhinal cortex (mEC) and hippocampus generate gamma frequency population rhythms independently. Temporal interaction between these areas at gamma frequencies is implicated in memory-a phenomenon linked to activity of NMDA-subtype glutamate receptors. While blockade of NMDA receptors does not affect frequency of gamma rhythms in hippocampus, it exposes a second, lower frequency (25-35 Hz) gamma rhythm in mEC In experiment and model, NMDA receptor-dependent mEC gamma rhythms were mediated by basket interneurons, but NMDA receptor-independent gamma rhythms were mediated by a novel interneuron subtype-the goblet cell. This cell was distinct from basket cells in morphology, intrinsic membrane properties and synaptic inputs. The two different gamma frequencies matched the different intrinsic frequencies in hippocampal areas CA3 and CA1, suggesting that NMDA receptor activation may control the nature of temporal interactions between mEC and hippocampus, thus influencing the pathway for information transfer between the two regions.

Publication metadata

Author(s): Middleton S, Jalics J, Kispersky T, Le Beau FEN, Roopun AK, Kopell NJ, Whittington MA, Cunningham MO

Publication type: Article

Publication status: Published

Journal: Proceedings of the National Academy of Sciences

Year: 2008

Volume: 105

Issue: 47

Pages: 18572-18577

ISSN (print): 0027-8424

ISSN (electronic): 1091-6490

Publisher: National Academy of Sciences

URL: http://dx.doi.org/10.1073/pnas.0809302105

DOI: 10.1073/pnas.0809302105

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