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Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhoood acute lymphoblastic leukemia

Lookup NU author(s): Kate Wilson, Marian Case, Lynne Minto, Professor Simon BaileyORCiD, Dr Nicholas Bown, Sally Lawson, Professor Hermann Josef Vormoor, Professor Julie Irving


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Flow cytometric minimal residual disease (MRD) monitoring could become more powerful if directed towards the disease-maintaining leukaemic stem cell (LSC) compartment. Using a cohort of 48 children with B lineage acute lymphoblastic leukamia (ALL), we sought the newly proposed candidate-LSC population, CD34+CD38lowCD19+, at presentation and in end of induction bone marrow samples. We identified the candidate LSC population in 60% of diagnostic samples and its presence correlated with expression of CD38, relative to that of normal B cell progenitors. In addition, the candidate LSC was not detectable in all MRD positive samples. The absence of the population in 40% of diagnostic and 40% of MRD positive samples does not support the use of this phenotype as a generic biomarker to track LSCs and suggests that that this phenotype may be an artifact of CD38 under-expression rather than a biologically distinct LSC population.

Publication metadata

Author(s): Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J

Publication type: Article

Publication status: Published

Journal: Haematologica

Year: 2009

Volume: 95

Issue: 4

Pages: 679-683

ISSN (print): 0390-6078

ISSN (electronic): 1592-8721

Publisher: Fondazione Ferrata Storti


DOI: 10.3324/haematol.2009.011726


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