Browse by author
Lookup NU author(s): Professor Jane Endicott,
Professor Martin Noble
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Protein kinases are attractive targets for rational drug design against a wide range of diseases. From detailed knowledge of the structure-function relationships underlying protein kinase activity and regulation, a number of methods for achieving kinase inhibition have been suggested and explored using structure-aided drug discovery. Attaining selective protein kinase inhibition in a cellular context, and converting the large number of known potent kinase inhibitors into effective drugs, are outstanding problems in this area and, from a structural perspective, the challenges presented by modulating pharmacokinetics and minimizing the incidence of resistant mutations in the target are of particular interest.
Author(s): Noble MEM; Endicott JA; Pratt DJ
Publication type: Review
Publication status: Published
Journal: Current Opinion In Drug Discovery & Development
ISSN (print): 1367-6733
ISSN (electronic): 2040-3437
Publisher: THOMSON SCIENTIFIC