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The cyclin box fold: protein recognition in cell-cycle and transcription control

Lookup NU author(s): Professor Martin NobleORCiD, Professor Jane Endicott


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Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.

Publication metadata

Author(s): Noble MEM; Endicott JA; Brown NR; Johnson LN

Publication type: Review

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 1997

Volume: 22

Issue: 12

Pages: 482-487

Print publication date: 01/12/1997

ISSN (print): 0968-0004

ISSN (electronic): 0167-7640



DOI: 10.1016/S0968-0004(97)01144-4